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Compound in Grapes, Red Wine Could be Key to Fighting Prostate Cancer

By Guest PostNovember 10, 2012Healthaggressive tumor, animal model, cancer, cardiovascular health, cell, chemotherapy, clinical trials, compound, granzyme b, grape skins, grocery stores, human health, michael nicholl, missouri, perforin, prostate cancer, prostate tumor, proteins, radiation therapy, radiation treatment, red wine, resveratrol, stroke prevention, therapeutic agent, university

MU researcher finds that prostate tumor cells are more susceptible to treatment after being exposed to resveratrol, a compound found in grape skins and red wine.

Resveratrol, a compound found commonly in grape skins and red wine, has been shown to have several beneficial effects on human health, including cardiovascular health and stroke prevention. Now, a University of Missouri researcher has discovered that the compound can make prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors.

“Other studies have noted that resveratrol made tumor cells more susceptible to chemotherapy, and we wanted to see if it had the same effect for radiation therapy,” said Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine. “We found that when exposed to the compound, the tumor cells were more susceptible to radiation treatment, but that the effect was greater than just treating with both compounds separately.” (more…)

Analysis of Bacterial Genes May Help ID Cause of Dog Brain Disease, Say UF Researchers

By Guest PostOctober 2, 2012Health, Nature, Scienceanalysis, autoimmune, bacteria, balance, brain damage, brain disorder, brain inflammation, brain syndrome, brain tissue, cell, central, chihuahuas, christopher mariani, daniel brown, decreased alertness, dina michaels, disease, dog, florida, gene, genetic makeup, genital tract, gme, granulomatous meningoencephalomyelitis, immune system, karen vernau, macrophages, malteses, mycoplasma canis, necrotizing meningoencephalitis, nervous system, nme, pomeranians, pugs, renee barber, response, scott schatzberg, seizures, small breed, symptom, throat, university, viral agent, virus, yorkshire terriers

GAINESVILLE, Fla. — By analyzing the genes of bacteria, University of Florida researchers have moved a step closer to pinpointing how two brain disorders common in small-breed dogs occur.

The researchers found that the bacteria, known as Mycoplasma canis, invade dog’s cells and suppress their immune system responses. (more…)

What’s that Noise?

By Guest PostSeptember 26, 2012Scienceabhyudai singh, brandon razooky, cell, delaware, expression, gene, hiv, hiv virus, human, immunodeficiency virus, leor weinberger, mrnas, new method, noise, protein level, roy dar, san francisco, source, university, variability

Paper describes new method to understand sources of noise in gene-expression

Abhyudai Singh, assistant professor of electrical and computer engineering at the University of Delaware, describes a new method to understand sources of “noise” in gene-expression that create variability in protein levels in a paper published in Molecular Systems Biology, a publication of Nature, on Aug. 28.

This noise is expressed as variability in the levels of proteins/mRNAs in a cell. (more…)

Relieving Plant Stress Could Eventually Help Humans Relax

By Guest PostSeptember 14, 2012Scienceanimal model, arabidopsis mutant, biologist, biotechnology, cell, cell material, coal mine, disease, Environment, federica brandizzi, human growth, humans, ire1, michigan, multifunctional protein, plant, protein, state university, stress

EAST LANSING, Mich. — Humans could learn from how plants handle stress.

Federica Brandizzi, Michigan State University plant biologist, is using a grant from the National Institutes of Health to study how plants overcome stress as they grow. These pathways used to overcome stress are a key to growth. Without them plants, and animals, would die.

“When cells grow, they undergo trauma as growth is quite stressful,” Brandizzi said. “Since it’s very likely that these pathways have much in common between humans and plants, we should be able to gain insights into how plants and animals overcome stress and continue to grow as well.” (more…)

UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

By Guest PostSeptember 5, 2012Health, Scienceblood, blood lineage, bone marrow, cell, diseases, gay crooks, gene, haystack, human, immune deficiency, immune function, immune system, infection, leukemia, lisa kohn, lymphocytes, missing link, needle, platelets, post natal life, progenitors, red blood cell, researcher, set, stem cell, type, ucla

UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)

To Cap or Not to Cap: Scientists Find New RNA Phenomenon That Challenges Dogma

By Guest PostSeptember 2, 2012Sciencebaskar bakthavachalu, brian kennedy, cancer, cell, cell life, chandrama mukherjee, cytoplasm, daniel schoenberg, deepak patil, embryonic development, gene, hibernation, messenger rna, mitotic cell cycle, molecule, mrna, neurological activity, ohio state university, protein, rna

COLUMBUS, Ohio – Some RNA molecules spend time in a restful state akin to hibernation rather than automatically carrying out their established job of delivering protein-building instructions in cells, new research suggests.

And instead of being a fluke or a mistake, the research suggests that this restful period appears to be a programmed step for RNA produced by certain types of genes, including some that control cell division and decide where proteins will work in a cell to sustain the cell’s life.

This could mean that protein production in cells is not as clear-cut as biology textbooks suggest, scientists say. (more…)

Cells in Blood Vessel Found To Cling More Tightly in Regions of Rapid Flow

By Guest PostApril 27, 2012Health, Sciencebenjamin shuman, biochemical change, blockage, cardiac surgeon, cardiovascular disease, cell, cholesterol, clogging, heart, joon jung, living organ, lucas ting, mechanical engineering, nathan sniadecki, sangyoon han, shirin feghhi, surgeon, tugging force, university of washington, vascular leakage

Clogging of pipes leading to the heart is the planet’s number one killer. Surgeons can act as medical plumbers to repair some blockages, but we don’t fully understand how this living organ deteriorates or repairs itself over time.

Researchers at the University of Washington have studied vessel walls and found the cells pull more tightly together, reducing vascular leakage, in areas of fast-flowing blood. The finding could influence how doctors design drugs to treat high cholesterol, or how cardiac surgeons plan their procedures. (more…)

Locked RNA Editing Yields Odd Fly Behavior

By Guest PostApril 26, 2012Scienceabiotic factor, als, arthur sugden, asli sahin, brown university, cell, charles lawrence, dadar, enzyme adar, epilepsy, factor, fruit fly, function, genetic, jacquelyn dorsky, james jepson, lauren alpert, locking down, lou gehrigs disease, nucleus, organism, phenomenon, protein, rna, robert reenan, suicidal depression, temperature, wallflowers, yiannis savva

At the level of proteins, organisms can adapt by editing their RNA — and an editor can even edit itself. Brown University scientists working with fruit flies found that “locking down” the self-editing process at two extremes created some strange behaviors. They also found that the process is significantly affected by temperature.

PROVIDENCE, R.I. [Brown University] — Because a function of RNA is to be translated as the genetic instructions for the protein-making machinery of cells, RNA editing is the body’s way of fine-tuning the proteins it produces, allowing us to adapt. The enzyme ADAR, which does this editing job in the nervous system of creatures ranging from mice to men, even edits itself. In a new study that examined the self-editing process and locked it down at two extremes in fruit flies, Brown University scientists found some surprising insights into how this “fine-tuning of the fine-tuner” happens, including bizarre behavioral effects that come about when the self-editor can’t edit. (more…)

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