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UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

By Guest PostSeptember 5, 2012Health, Scienceblood, blood lineage, bone marrow, cell, diseases, gay crooks, gene, haystack, human, immune deficiency, immune function, immune system, infection, leukemia, lisa kohn, lymphocytes, missing link, needle, platelets, post natal life, progenitors, red blood cell, researcher, set, stem cell, type, ucla

UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.

The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)

Blood Discovery

By Guest PostMay 3, 2012Sciencea, arteries, blood clot, England, heart disease, intravital microscope, jam a protein, jonathan m gibbins, junctional adhesion molecule, lawrence brass, local cardiologist, meghna naik, plaque lines, platelets, protein in blood, stroke, ulhas naik, university of delaware, university of reading, world health organization

UD researchers discover that JAM-A protein keeps blood clots in check

Cut your toe, and platelets — those disc-shaped cells circulating in your blood — rush to the scene, clumping together to plug the leak.

But when an unwanted clot forms in an artery, and an overaccumulation of platelets blocks blood flow, a heart attack or stroke occurs, too often with fatal results.

Heart disease and stroke rank as humankind’s top killers, according to the World Health Organization. Ulhas Naik, director of the Delaware Cardiovascular Research Center at the University of Delaware, hopes to help change that grim statistic for the better. (more…)

How Megakaryocytes Get so Big — and The Bad Things That Happen When They Don’t

By Guest PostMarch 2, 2012Scienceblood cells, cell division, diane krause, DNA, ect2, ee chun cheng, elenoe smith, endomitosis, gef h1, gene, giant blood cells, guanine exchange factors, krause lab, leukemia, lin wang, malfunction, malignant leukemias, megakaryoblastic leukemias, megakaryocyte maturation, megakaryocytes, mkl1, mutant, platelets, process, protein, sharon lin, siying zou, stephanie halene, supernova, yuan gao

Yale researchers have discovered how megakaryocytes — giant blood cells that produce wound-healing platelets — manage to grow 10 to 15 times larger than other blood cells.

The findings, to be published March 13 in the journal Developmental Cell, also hint at how a malfunction in this process may cause a form of leukemia. (more…)

Chemists Unlock Potential Target For Drug Development

By Guest PostJanuary 22, 2012Scienceadditives, analytical methods, bleeding, blood flow, blood platelets, bloodstream, clotting, cystic fibrosis, dana spence, diabetes, diseases, drug testing, druggable receptors, enzymes, human body, hypertension, michigan state university, molecule, nf449, p2x1, p2y receptor, pharmaceutical target, platelets, receptor, red blood cells, sickle cell anemia

EAST LANSING, Mich. — A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists.

A team led by Dana Spence of MSU’s Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that impact red blood cells, such as diabetes, hypertension and cystic fibrosis. (more…)

Tag Archives: platelets

UCLA Scientists Discover ‘Missing Link’ Between Blood Stem Cells, Immune System

Blood Discovery

How Megakaryocytes Get so Big — and The Bad Things That Happen When They Don’t

Chemists Unlock Potential Target For Drug Development