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Bacteria can pass on memory to descendants, UCLA-led team discovers

By Guest PostSeptember 8, 2018Healthbacteria, cystic fibrosis, generation of cells, george otoole, gerard wong, memory, pass, pseudomonas aeruginosa, ramin golestanian

Findings are a major step toward understanding persistent infections that affect people with cystic fibrosis

Led by scientists at UCLA, an international team of researchers has discovered that bacteria have a “memory” that passes sensory knowledge from one generation of cells to the next, all without a central nervous system or any neurons. (more…)

Research Shows Why One Bacterial Infection is So Deadly in Cystic Fibrosis

By Guest PostApril 28, 2012Scienceacute infection, amal amer, antibiotics, anwari akhter, arwa abu khweek, autophagy, bacterial infection, bacterium, basant abdulrahman, benjamin kopp, burkholderia cenocepacia, cf, chronic destruction, cystic fibrosis, genetic mutation, kyle caution, lung infection, lung tissue, macrophage, mia tazi, mice and humans, molecule, ohio state university, p62, rapamycin

COLUMBUS, Ohio – Scientists have found why a certain type of bacteria, harmless in healthy people, is so deadly to patients with cystic fibrosis.

The bacterium, Burkholderia cenocepacia, causes a severe and persistent lung infection in patients with CF and is resistant to nearly all known antibiotics. Cystic fibrosis is a chronic disorder characterized by a buildup of mucus in the lungs and other parts of the body, and various types of lung infection are responsible for about 85 percent of deaths in these patients. (more…)

Chemists Unlock Potential Target For Drug Development

By Guest PostJanuary 22, 2012Scienceadditives, analytical methods, bleeding, blood flow, blood platelets, bloodstream, clotting, cystic fibrosis, dana spence, diabetes, diseases, drug testing, druggable receptors, enzymes, human body, hypertension, michigan state university, molecule, nf449, p2x1, p2y receptor, pharmaceutical target, platelets, receptor, red blood cells, sickle cell anemia

EAST LANSING, Mich. — A receptor found on blood platelets whose importance as a potential pharmaceutical target has long been questioned may in fact be fruitful in drug testing, according to new research from Michigan State University chemists.

A team led by Dana Spence of MSU’s Department of Chemistry has revealed a way to isolate and test the receptor known as P2X1. By creating a new, simple method to study it after blood is drawn, the team has unlocked a potential new drug target for many diseases that impact red blood cells, such as diabetes, hypertension and cystic fibrosis. (more…)

What Bacteria Don’t Know Can Hurt Them

By Guest PostJanuary 20, 2012Scienceactual infections, amruta joshi datar, antibiotic, antibiotic resistance, antibiotic sensitive bacteria, antibiotic targets, bacteria, bacteria in biofilms, bacterial functions, biofilm, cells, chronic wounds, cystic fibrosis, dao nguyen, elizabeth bauerle, infection, karlyn beer, lungs, mcgill university, metabolism, microbiologist, natural environment, nutrient, oxygen, paradox, pradeep singh, radicals, resistance, richard siehnel, starvation, starved bacteria, toxic forms, toxic radicals

Many infections, even those caused by antibiotic-sensitive bacteria, resist treatment. This paradox has vexed physicians for decades, and makes some infections impossible to cure.

A key cause of this resistance is that bacteria become starved for nutrients during infection. Starved bacteria resist killing by nearly every type of antibiotic, even ones they have never been exposed to before. (more…)

Novel Nanoparticle Mimicking Virus Offers New Route to Gene Therapy

By Guest PostDecember 10, 2011Sciencebrain tumors, cancer, caroline e weller, christopher j cheng, cystic fibrosis, diseases, gene therapy, healthy cells, huntingtons disease, hydrophobic, immune reactions, materials, mouse tumor model, nanoparticle, non viral gene therapy, novel chemistry, polymers, positive electric charge, repair, symptoms, treatments, viral gene therapy, w mark saltzman, water molecules, water repellant, yale university, zhaozhong jiang

Researchers at Yale University have developed a novel nanoparticle with promising applications in gene therapy, a type of medical treatment that addresses the root causes of diseases now typically treated for symptoms.

The advance could lead to new therapies for many forms of cancer, including brain tumors, as well as for cystic fibrosis and Huntington’s Disease. (more…)

WHOI Teaming with Flatley Discovery Lab in Search for Effective Treatments for Cystic Fibrosis

By Guest PostOctober 13, 2011Health, Scienceantibiotics, biological and chemical processes of ocean microbes, cf, cftr, cftr gene, charlestown, chemical extracts, cystic fibrosis, cystic fibrosis trans-membrane conductance regulator, flatley discovery lab, fungi, gene, john flatley, marine actinomycetes, marine microbes, marine microbial extracts, membrane, microbes, microbial infection biofilm, mutation, phytoplankton, respiratory disease, richard fitzpatrick, sodium transport, susan k. avery, therapeutic agents for cystic fibrosis, tracy mincer, whoi, woods hole oceanographic institution

The Woods Hole Oceanographic Institution (WHOI) has signed a $1.18 million agreement with the Flatley Discovery Lab in Charlestown, Mass., to investigate and supply marine microbial extracts as possible treatments for cystic fibrosis (CF).

The life-shortening respiratory disease has eluded attempts at a cure, although researchers have been successful in some cases at adding years to a person’s lifespan, primarily through treatment with antibiotics. (more…)

One Step Closer to a Drug Treatment for Cystic Fibrosis, MU Professor Says

By Guest PostOctober 13, 20101 commentHealth, Scienceatp, cell, cftr, chloride channels, cystic fibrosis, cystic fibrosis transmembrane conductance regulator, drug, fatal genetic diseases, genetic mutations, paper of the week, protein, tzyh chang hwang, university of missouri

*Study recognized for significance and importance in the world’s most common genetic disease*

COLUMBIA, Mo. – A University of Missouri researcher believes his latest work moves scientists closer to a cure for cystic fibrosis, one of the world’s most common fatal genetic diseases. (more…)

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