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Staphylococcus aureus bacteria turns immune system against itself

By Guest PostDecember 6, 2013Healthadenosine synthase a, adsa gene, antibiotic resistant strain, bloodstream, dado, deoxyadenosine, destroy, DNA, dominique m missiakas, human function, immune defense mechanism, immune system, kevin jiang, macrophage, mrsa, mutation, nets, neutrophil extracellular traps, nuc, olaf schneewind, protein, s. aureus, staphylococcal nuclease, staphylococcus aureus bacteria, university of chicago, vilasack thammavongsa, white blood cells

Around 20 percent of all humans are persistently colonized with Staphylococcus aureus bacteria, a leading cause of skin infections and one of the major sources of hospital-acquired infections, including the antibiotic-resistant strain MRSA.

University of Chicago scientists have recently discovered one of the keys to the immense success of S. aureus—the ability to hijack a primary human immune defense mechanism and use it to destroy white blood cells. The study was published Nov. 15 in Science. (more…)

Research Shows Why One Bacterial Infection is So Deadly in Cystic Fibrosis

By Guest PostApril 28, 2012Scienceacute infection, amal amer, antibiotics, anwari akhter, arwa abu khweek, autophagy, bacterial infection, bacterium, basant abdulrahman, benjamin kopp, burkholderia cenocepacia, cf, chronic destruction, cystic fibrosis, genetic mutation, kyle caution, lung infection, lung tissue, macrophage, mia tazi, mice and humans, molecule, ohio state university, p62, rapamycin

COLUMBUS, Ohio – Scientists have found why a certain type of bacteria, harmless in healthy people, is so deadly to patients with cystic fibrosis.

The bacterium, Burkholderia cenocepacia, causes a severe and persistent lung infection in patients with CF and is resistant to nearly all known antibiotics. Cystic fibrosis is a chronic disorder characterized by a buildup of mucus in the lungs and other parts of the body, and various types of lung infection are responsible for about 85 percent of deaths in these patients. (more…)

Yale Researchers Identify Four Key Weapons in Immune System’s Arsenal

By Guest PostMay 7, 2011Health4 key weapons, bacterial infections, deliver antimicrobial enzymes, food-borne bacteria, gastrointestinal illness, gtpases, hepatitis c, immune-compromised, interferon therapy, john d. macmicking, macrophage, marshal immune system, microbial pathogenesis, mimic, noxious chemicals, pathogens, pulmonary diseases, tuberculosis, variety of pathogens, winchester fund and cancer research institute, yale university

Yale University researchers have identified four unique host defense proteins among thousands that seem to play a crucial role in mobilizing the immune system’s response to bacterial infections, they report in the May 6 issue of the journal Science.

The findings suggest it may be possible to find new ways to assist immune-compromised patients to fight off a variety of pathogens, the authors say.

“We can start to think about how to mimic these chemical processes and deliver them in drug form,” said John D. MacMicking, associate professor of microbial pathogenesis at Yale School of Medicine and senior author the study. (more…)

Tag Archives: macrophage

Staphylococcus aureus bacteria turns immune system against itself

Research Shows Why One Bacterial Infection is So Deadly in Cystic Fibrosis

Yale Researchers Identify Four Key Weapons in Immune System’s Arsenal