Cryo electron microscope enables scientists to explore the frontiers of targeted antibiotics
Researchers at UCLA’s California NanoSystems Institute have become the first to produce images of the atomic structures of three specific biological nanomachines, each derived from a different potentially deadly bacterium — an achievement they hope will lead to antibiotics targeted toward specific pathogens. (more…)
For older adults, being unable to identify scents is a strong predictor of death within five years, according to a study published Oct. 1 in the journal PLOS ONE. Thirty-nine percent of study subjects who failed a simple smelling test died during that period, compared to 19 percent of those with moderate smell loss and just 10 percent of those with a healthy sense of smell. (more…)
Gates Foundation funds civil engineering professor’s novel wastewater treatment fabric
Each year in India, waterborne diseases sicken approximately 37.7 million people. One and a half million children die of diarrhea alone, according to a report by WaterAid.
In the developing world, open pit latrines are common, but they pose a significant risk to public health and the environment. Open pit latrines can be as sophisticated as an outhouse or as simple as a trench in the ground. (more…)
To safely use bacteria in agriculture to help fertilize crops, it is vital to understand the difference between harmful and healthy strains. The bacterial genus Burkholderia, for example, includes dangerous disease-causing pathogens — one species has even been listed as a potential bioterrorist agent — but also many species that are safe and important for plant development.
Can the microbial good and evil be told apart? Yes, UCLA life scientists and an international team of researchers report Jan. 8 in the online journal PLOS ONE. (more…)
Initial, positive results have been reported for a therapeutic vaccine candidate for treating patients with genital herpes. This first-in-class, investigational, protein subunit vaccine, GEN-003, is under development by Genocea Biosciences Inc.
Dr. Anna Wald, University of Washington professor of medicine and laboratory medicine in the School of Medicine and professor of epidemiology in the School of Public Health, is among those leading clinical studies of GEN-003. The trials are also taking place at six other centers in the United States. (more…)
AMHERST, Mass. – When microbiologist James Holden of the University of Massachusetts Amherst launches new studies next month of the microbes living deep in the cracks and thermal vents around an undersea volcano, for the first time in his 25-year career his deep-sea research will not be funded by a government source.
Instead, Holden will be funded by philanthropists committed to supporting oceanographic research: The Gordon and Betty Moore Foundation started by the co-founder of Intel and his wife, and the Schmidt Ocean Institute (SOI), started by Eric Schmidt of Google and his wife, Wendy. The Moores’ foundation is dedicated to advancing environmental conservation and scientific research, while the SOI supports oceanographic research projects that “help expand the understanding of the world’s oceans through technological advancements, intelligent observation and analysis, and open sharing of information.” (more…)
Knowing the temperatures that viruses, bacteria, worms and all other parasites need to grow and survive could help determine the future range of infectious diseases under climate change, according to new research.
Princeton University researchers developed a model that can identify the prospects for nearly any disease-causing parasite as the Earth grows warmer, even if little is known about the organism. Their method calculates how the projected temperature change for an area would alter the creature’s metabolism and life cycle, the researchers report in the journal Ecology Letters. (more…)
Misguided killer T cells may be the missing link in sustained tissue damage in the brains and spines of people with multiple sclerosis, findings from the University of Washington reveal. Cytoxic T cells, also known as CD8+ T cells, are white blood cells that normally are in the body’s arsenal to fight disease.
Multiple sclerosis is characterized by inflamed lesions that damage the insulation surrounding nerve fibers and destroy the axons, electrical impulse conductors that look like long, branching projections. Affected nerves fail to transmit signals effectively. (more…)
