Nanopores could provide a new way to sequence DNA quickly, but the physics involved isn’t well understood. That’s partly because of the complexities involved in studying the random, squiggly form DNA takes in solution. Researchers from Brown have simplified matters by using a stiff, rod-like virus instead of DNA to experiment with nanopores. Their research has uncovered previously unknown dynamics in polymer-nanopore interactions.
PROVIDENCE, R.I. [Brown University] — Nanopores may one day lead a revolution in DNA sequencing. By sliding DNA molecules one at a time through tiny holes in a thin membrane, it may be possible to decode long stretches of DNA at lightning speeds. Scientists, however, haven’t quite figured out the physics of how polymer strands like DNA interact with nanopores. Now, with the help of a particular type of virus, researchers from Brown University have shed new light on this nanoscale physics. (more…)