Tag Archives: georgios skiniotis

Architecture of signaling proteins enhances knowledge of key receptors

ANN ARBOR — A team of scientists from the University of Michigan, Duke Medicine and Stanford University has determined the underlying architecture of a cellular signaling complex involved in the body’s response to stimuli such as light and pain.

This complex, consisting of a human cell surface receptor and its regulatory protein, reveals a two-step mechanism that has been hypothesized previously but not directly documented. (more…)

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Decoding dengue and West Nile: Researchers take steps toward control of growing public health problems

ANN ARBOR — Dengue fever and West Nile fever are mosquito-borne diseases that affect hundreds of millions of people worldwide each year, but there is no vaccine against either of the related viruses.

A team of scientists at the University of Michigan and Purdue University has discovered a key aspect both to how the viruses replicate in the cells of their host and how they manipulate the immune system as they spread. (more…)

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