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Architecture of signaling proteins enhances knowledge of key receptors

ANN ARBOR — A team of scientists from the University of Michigan, Duke Medicine and Stanford University has determined the underlying architecture of a cellular signaling complex involved in the body’s response to stimuli such as light and pain.

This complex, consisting of a human cell surface receptor and its regulatory protein, reveals a two-step mechanism that has been hypothesized previously but not directly documented. (more…)

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