*Study implicates “arms race” between genes and germs*
Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs–even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.
“Major histocompatibility complex” (MHC) proteins are found on the surfaces of most cells in vertebrate animals. They distinguish proteins like themselves from foreign proteins, and trigger an immune response against these foreign invaders. (more…)
EAST LANSING, Mich. — Continuing a global effort to prevent malaria infections, Michigan State University researchers have created a new malaria vaccine – one that combines the use of a disabled cold virus with an immune system-stimulating gene – that appears to increase the immune response against the parasite that causes the deadly disease.
At the same time, the group led by Andrea Amalfitano of the College of Osteopathic Medicine also discovered another immune-system stimulating agent – created at MSU and which has been successful in improving immune responses in vaccines for diseases such as HIV – paradoxically made for a less effective malaria vaccine. (more…)
UCLA life scientists and their colleagues have discovered the first evidence of the H1N1 virus in animals in Africa. In one village in northern Cameroon, a staggering 89 percent of the pigs studied had been exposed to the H1N1 virus, commonly known as the swine flu.
“I was amazed that virtually every pig in this village was exposed,” said Thomas B. Smith, director of UCLA’s Center for Tropical Research and the senior author of the research. “Africa is ground zero for a new pandemic. Many people are in poor health there, and disease can spread very rapidly without authorities knowing about it.” (more…)
GAINESVILLE, Fla. — Rates of HIV have increased in Pakistan’s general population, as the virus has spread beyond at-risk groups to women and their children, according to an international team of researchers, including a University of Florida scientist.
The researchers raise concern that the transmission across subgroups into Pakistan’s general population may serve as indication that the virus may be spreading into populations within neighboring Afghanistan. The team’s epidemiological findings were published in July in the journal PLoS One. (more…)
*Intervention focuses on couples in which one partner is HIV-positive*
Intervention programs that promote healthier eating, increased physical activity and cancer screenings may be beneficial for African American couples that are at high risk for chronic diseases and that include one partner who is HIV-positive, according to new research.
With such inverventions, each partner appears to draw encouragement from the other to monitor his or her own lifestyle and health, according to study co-author Gail Wyatt, a professor of psychiatry and biobehavioral sciences at the Semel Institute for Neuroscience and Human Behavior at UCLA and an associate director of the UCLA AIDS Institute.(more…)
In the early years of the AIDS epidemic, being infected with the virus that causes the disease was considered a virtual death sentence. But with the development of antiretroviral therapy, many with HIV are now living much longer. In fact, it is estimated that by 2015, about half of all HIV-positive individuals will be older than 50.
Yet those over 50 also progress to AIDS faster than adults in their 20s or 30s. And those in the younger age bracket — even those responding well to antiretroviral therapy — still exhibit illnesses and clinical conditions commonly associated with older people, such as certain cancers and liver diseases. For the most part, the reasons for this have remained a mystery. (more…)
A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS
Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.
But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.
UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say.(more…)
