The enzyme-linked immunosorbent assay is one of the most sensitive biochemical or immunological tests. It is used a lot in medicine to detect presence or absence of antibodies raised to fight antigens or the specific antigen. The sensitivity of the test results from reliance on enzymes. As you are well aware, enzymes are highly specific. (more…)
A spark from a lightning bolt, interstellar dust, or a subsea volcano could have triggered the very first life on Earth.
But what happened next? Life can exist without oxygen, but without plentiful nitrogen to build genes – essential to viruses, bacteria and all other organisms – life on the early Earth would have been scarce.(more…)
Researchers at UD use ancient gene to study virus biology
Researchers at the University of Delaware have discovered that an ancient gene — ribonucleotide reductase (RNR), which occurs in all cellular life — provides important biological insights into the characteristics of unknown viruses in the sea. (more…)
Researchers at Yale School of Medicine have pinpointed a mechanism in part of the brain that is key to sensing glucose levels in the blood, linking it to both type 1 and type 2 diabetes. The findings are published in the July 28 issue of Proceedings of the National Academies of Sciences.
“We’ve discovered that the prolyl endopeptidase enzyme — located in a part of the hypothalamus known as the ventromedial nucleus — sets a series of steps in motion that control glucose levels in the blood,” said lead author Sabrina Diano, professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences, Comparative Medicine, and Neurobiology at Yale School of Medicine. “Our findings could eventually lead to new treatments for diabetes.” (more…)
Enzyme map created by using a high-powered X-ray device
COLUMBIA, Mo. – The human body is full of proteins called enzymes that help nearly every function in the body. Scientists have been studying enzymes for decades in order to learn how they work and how to create better drugs and medical treatments for many ailments. Now, University of Missouri researchers have completed a 3-D map of an enzyme called Proline utilization A (PutA). PutA facilitates metabolism by adding oxygen to molecules. John Tanner, a professor in the MU Department of Biochemistry, says mapping this enzyme will give researchers a better understanding of its function, which could help drug manufacturers create more effective drugs. (more…)