Tag Archives: current rate

Mulling the marijuana munchies: How the brain flips the hunger switch

The “munchies,” or that uncontrollable urge to eat after using marijuana, appear to be driven by neurons in the brain that are normally involved in suppressing appetite, according to a new study by Yale School of Medicine researchers in the Feb. 18 issue of the journal Nature.

Lead author Tamas Horvath and his colleagues set out to monitor the brain circuitry that promotes eating by selectively manipulating the cellular pathway that mediates marijuana’s action on the brain, using transgenic mice. (more…)

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Glucose ‘control switch’ in the brain key to both types of diabetes

Researchers at Yale School of Medicine have pinpointed a mechanism in part of the brain that is key to sensing glucose levels in the blood, linking it to both type 1 and type 2 diabetes. The findings are published in the July 28 issue of Proceedings of the National Academies of Sciences.

“We’ve discovered that the prolyl endopeptidase enzyme — located in a part of the hypothalamus known as the ventromedial nucleus — sets a series of steps in motion that control glucose levels in the blood,” said lead author Sabrina Diano, professor in the Departments of Obstetrics, Gynecology & Reproductive Sciences, Comparative Medicine, and Neurobiology at Yale School of Medicine. “Our findings could eventually lead to new treatments for diabetes.” (more…)

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