Organisms discovered by Yale undergraduates growing within fungi in the Amazon Rainforest can degrade polyurethane, a findings that may lead to innovative ways to reduce waste in the world’s landfills.
The paper, accepted for publication in July by the journal Applied and Environmental Microbiology, is the work of undergraduates who participated in Yale’s Rainforest Expedition and Laboratory course, funded by the Howard Hughes Medical Institute. (more…)
COLUMBUS, Ohio – Researchers who have been working for nearly a decade to piece together the process by which an enzyme repairs sun-damaged DNA have finally witnessed the entire process in full detail in the laboratory.
What they saw contradicts fundamental notions of how key biological molecules break up during the repair of sunburn – and that knowledge could someday lead to drugs or even lotions that could heal sunburn in humans. (more…)
AUSTIN, Texas — Atlantic croaker living in the large Gulf of Mexico “Dead Zone” exhibit severe reproductive impairment with potential long-term impacts on the fish’s population abundance, researchers from The University of Texas at Austin’s Marine Science Institute have found.
Males and females were found to produce dramatically fewer sperm and eggs. In addition, females in the hypoxic Dead Zone waters were masculinized — some 20 percent actually produced sperm in their ovaries. The sex ratio was also heavily skewed toward males in the hypoxic area. (more…)
COLUMBUS, Ohio – Chronic inhalation of polluted air appears to activate a protein that triggers the release of white blood cells, setting off events that lead to widespread inflammation, according to new research in an animal model.
This finding narrows the gap in researchers’ understanding of how prolonged exposure to pollution can increase the risk for cardiovascular problems and other diseases. (more…)
COLUMBUS, Ohio — A spoonful of sugar may be enough to cool a hot temper, at least for a short time, according to new research.
A study found that people who drank a glass of lemonade sweetened with sugar acted less aggressively toward a stranger a few minutes later than did people who consumed lemonade with a sugar substitute.
Researchers believe it all has to do with the glucose, a simple sugar found in the bloodstream that provides energy for the brain. (more…)
A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS
Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.
But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell.
UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say.(more…)
John Tanner, who also teaches chemistry in the College of Arts and Science, is studying Aspergillus fumigatus. Image credit: University of Missouri
COLUMBIA, Mo. – If finding the cure for a fungus and parasite that affects millions of people were the subject of a detective show, University of Missouri Chemistry Professor John Tanner would be the forensic expert in the lab, using high-tech equipment to make a model that could eventually solve the crime.
Tanner, who also teaches chemistry in the College of Arts and Science, has joined forces with Pablo Sobrado, an assistant professor of biochemistry at Virginia Tech, to study a unique enzyme found on two “crime scenes”: in Aspergillus fumigatus, a fungus that causes pulmonary diseases in immuno-compromised people; and in a blood-sucking insect prevalent in South America and now being found in the southwestern U.S., called the Chagas parasite, also known as the “kissing bug” for the red welts left on the victims’ faces after being bitten in his or her sleep.
“My job is to figure out what the enzyme looks like using X-ray diffraction,” Tanner said. “This enzyme makes a special sugar molecule that these organisms need to survive, so if we can find a way to stop the reaction that makes that sugar, then we might find a way to kill these pathogens.” (more…)
COLLEGE PARK, Md. — A team of neuroscientists has discovered important new information in the search for an effective treatment for Alzheimer’s disease, the debilitating neurological disorder that afflicts more than 5.3 million Americans and is the sixth-leading cause of death in the United States. Hey-Kyoung Lee , associate professor in the University of Maryland Department of Biology, and her research team have shown that they may be able to eliminate debilitating side effects caused by a promising Alzheimer’s drug by stimulating the brain’s nicotine receptors. (more…)
