Tag Archives: physiology

Nobels explained

UD faculty members discuss 2013 prize-winners at annual symposium

Today’s chemists might work at a computer as often as in a laboratory, medical researchers studying conditions such as diabetes rely on understanding how cells carry and deposit materials within the body, and average investors in the market increasingly buy index funds to average out the short-term ups and downs of individual stocks.

The discoveries that led to these changes are among the work that was honored by this year’s Nobel Prizes. (more…)

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Blades and Clades: Why Some Grasses Got Better Photosynthesis

Two groups — clades — of grasses that once had a common ancestry diverged. The PACMAD clade was predisposed to evolve a more efficient “C4” means of photosynthesis than grasses in the BEP clade. In a new study in the Proceedings of the National Academy of Sciences, a Brown-led team pinpoints the anatomical differences between the clades that led to the PACMAD’s tendency toward C4.

PROVIDENCE, R.I. [Brown University] — Even on the evolutionary time scale of tens of millions of years there is such a thing as being in the right shape at the right time. An anatomical difference in the ability to seize the moment, according to a study led by Brown University biologists, explains why more species in one broad group, or clade, of grasses evolved a more efficient means of photosynthesis than species in another clade. (more…)

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Science Working to Combat Deadly White Nose Syndrome in Bats

New findings on white-nose syndrome are bringing scientists closer to slowing the spread of this deadly bat disease, according to recent and ongoing studies by the U.S. Geological Survey.

WNS has killed more than 5 million bats since it first appeared in New York in 2007, and the disease, caused by the fungus Geomyces destructans, has spread to 19 U.S. states and four Canadian provinces (view map). (more…)

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Establish Healthy Traditions to Make Winter Fun, Prevent Cold-Weather Blues, MU Experts Say

COLUMBIA, Mo. – Frigid weather may seem like a good excuse to avoid workouts, stay inside and overindulge in comfort foods. However, health experts from the University of Missouri have found that these tendencies leave most people feeling less content during the winter months. MU researchers say people should establish new traditions to increase happiness and avoid wintertime woes.   (more…)

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New 3-D Model of RNA ‘Core Domain’ of Enzyme Telomerase May Offer Clues to Cancer, Aging

A model representation of telomerase's RNA "core domain," determined by Juli Feigon, Qi Zhang and colleagues in Feigon's UCLA laboratory. Image credit: Juli Feigon, UCLA Chemistry and Biochemistry/PNAS

Telomerase is an enzyme that maintains the DNA at the ends of our chromosomes, known as telomeres. In the absence of telomerase activity, every time our cells divide, our telomeres get shorter. This is part of the natural aging process, as most cells in the human body do not have much active telomerase. Eventually, these DNA-containing telomeres, which act as protective caps at the ends of chromosomes, become so short that the cells die.

 

But in some cells, such as cancer cells, telomerase, which is composed of RNA and proteins, is highly active and adds telomere DNA, preventing telomere shortening and extending the life of the cell. 

UCLA biochemists have now produced a three-dimensional structural model of the RNA “core domain” of the telomerase enzyme. Because telomerase plays a surprisingly important role in cancer and aging, understanding its structure could lead to new approaches for treating disease, the researchers say.  (more…)

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