Tag Archives: alzheimer

Copper on the Brain at Rest: Berkeley Lab Reports Proper Copper Levels Essential to Spontaneous Neural Activity

In recent years it has been established that copper plays an essential role in the health of the human brain. Improper copper oxidation has been linked to several neurological disorders including Alzheimer’s, Parkinson’s, Menkes’ and Wilson’s. Copper has also been identified as a critical ingredient in the enzymes that activate the brain’s neurotransmitters in response to stimuli. Now a new study by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has shown that proper copper levels are also essential to the health of the brain at rest. (more…)

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Memory loss associated with Alzheimer’s reversed for first time

Small trial by UCLA and Buck Institute succeeds using ‘systems approach’ to memory disorders

Patient 1 had two years of progressive memory loss. She was considering quitting her job, which involved analyzing data and writing reports, she got disoriented driving, and she mixed up the names of her pets.

Patient 2 kept forgetting once-familiar faces at work, forgot his gym locker combination and had to have his assistants constantly remind him of his work schedule. (more…)

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Link between vitamin D and dementia risk confirmed

Vitamin D deficiency is associated with a substantially increased risk of dementia and Alzheimer’s disease in older people, according to the most robust study of its kind ever conducted.

An international team, led by Dr David Llewellyn at the University of Exeter Medical School, found that study participants who were severely Vitamin D deficient were more than twice as likely to develop dementia and Alzheimer’s disease.

The team studied elderly Americans who took part in the Cardiovascular Health Study. They discovered that adults in the study who were moderately deficient in vitamin D had a 53 per cent increased risk of developing dementia of any kind, and the risk increased to 125 per cent in those who were severely deficient. (more…)

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UCLA researchers discover new gene involved in Parkinson’s disease

Finding may lead to new target for treatment

In the past decade, scientists have identified a handful of genes connected with Parkinson’s disease. Now, a team of UCLA researchers has identified another gene involved in the neurological disorder. Their finding may provide a target for drugs that could one day prevent or even cure the debilitating illness. (more…)

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How a Silly Putty ingredient could advance stem cell therapies

ANN ARBOR — The sponginess of the environment where human embryonic stem cells are growing affects the type of specialized cells they eventually become, a University of Michigan study shows.

The researchers coaxed human embryonic stem cells to turn into working spinal cord cells more efficiently by growing the cells on a soft, utrafine carpet made of a key ingredient in Silly Putty. Their study is published online at Nature Materials on April 13. (more…)

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Neurons in the Brain Tune into Different Frequencies for Different Spatial Memory Tasks

AUSTIN, Texas — Your brain transmits information about your current location and memories of past locations over the same neural pathways using different frequencies of a rhythmic electrical activity called gamma waves, report neuroscientists at The University of Texas at Austin.

The research, published in the journal Neuron on April 17, may provide insight into the cognitive and memory disruptions seen in diseases such as schizophrenia and Alzheimer’s, in which gamma waves are disturbed. (more…)

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Aufbau von Cholesterin-Transporter entschlüsselt

Die detaillierte dreidimensionale Struktur des Transport-Proteins TSPO
eröffnet neue Wege für die Diagnostik und Therapie bestimmter Krankheiten

Wenn sie das Wort „Cholesterin“ hören, denken die meisten Menschen unvermittelt an zu fettiges Essen, schlechte Blutwerte und Herz-Kreislauf-Erkrankungen. Trotz seines Rufs ist Cholesterin für uns jedoch unverzichtbar: Es stabilisiert die Membranen unserer Zellen und ist Rohstoff für die Produktion verschiedener Hormone in den Kraftwerken der Zelle, den Mitochondrien. Göttinger Forscher haben nun erstmals im atomaren Detail die Struktur des molekularen Transporters TSPO aufgeklärt, der Cholesterin in die Mitochondrien einschleust. Zugleich dient TSPO als Andockstelle für diagnostische Marker und verschiedene Medikamente wie zum Beispiel Valium. Die detaillierten Kenntnisse seiner dreidimensionalen Form und Funktion eröffnen neue diagnostische und therapeutische Perspektiven. (Science, 21. März 2014) (more…)

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Im Schlaf gemeinsam Gutes tun

Samsung Österreich und die Fakultät für Lebenswissenschaften der Universität Wien haben heute den Startschuss für eine großangelegte nationale Initiative gegeben: Unter dem Namen “Power Sleep” wollen die beiden Partner Smartphone- und Tablet-User in ganz Österreich dazu anregen, die Forschung im Kampf gegen Krankheiten wie Alzheimer oder Krebs voranzutreiben. Erreicht werden soll dies über eine eigens entwickelte Android-App: Sie erlaubt die nicht benötigte Prozessorleistung der mobilen Endgeräte der wissenschaftlichen Forschung zu spenden – etwa während man schläft. 

“Technologie kann nur in den Händen der Menschen Großes vollbringen. Was Thomas Rattei und sein Team an der Universität Wien in der Proteinforschung mit IT-Unterstützung und wissenschaftlichem Know-how leisten, hat uns inspiriert. Unsere Anerkennung dafür – und gleichzeitig unser Beitrag für den Kampf gegen Alzheimer oder Krebs – heißt Power Sleep”, erklärt Martin Wallner, Senior Director IT & Mobile bei Samsung Electronics Austria.  (more…)

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