A team of academic researchers has identified the intracellular mechanisms regulated by vitamin D3 that may help the body clear the brain of amyloid beta, the main component of plaques associated with Alzheimer’s disease.
Published in the March 6 issue of the Journal of Alzheimer’s Disease, the early findings show that vitamin D3 may activate key genes and cellular signaling networks to help stimulate the immune system to clear the amyloid-beta protein. (more…)
Where does it begin, the act of becoming a scientist? Perhaps with a bowling ball, its finger holes packed with explosives, which when detonated, launch the ball into the air, cracking the otherwise pristine concrete walkway of your childhood home in four places, much to the consternation of your father. Or maybe with an explosion of homemade rocket fuel in your basement chemistry lab that scares your mother half to death. And all this before the troublesome teen years.
Bob Vince can’t be sure where his becoming a scientist began. But where it led changed the world. (more…)
*Mechanism holds potential for improving recall in dementia patients*
Have you ever gone to the movies and forgotten where you parked the car? New UCLA research may one day help you improve your memory.
UCLA neuroscientists have demonstrated that they can strengthen memory in human patients by stimulating a critical junction in the brain. Published in the Feb. 9 edition of the New England Journal of Medicine, the finding could lead to a new method for boosting memory in patients with early Alzheimer’s disease.(more…)
*As we begin the New Year, a look at some of the stories of futuristic scenarios brought to life in 2011, plus developments that promise dramatic improvements in the near future.*
REDMOND, Wash. – Jan. 3, 2012 – From revolutionizing the way we interact with computers to developing tools to speed development of cures for crippling diseases, 2011 was a year of forward-thinking breakthroughs at Microsoft. See some of the innovations introduced in 2011 and how Microsoft is working to take new technologies from the lab to the living room. (more…)
*Proprotein convertases are enzymes that activate many essential proteins, but they are also implicated in many processes that cause disease. In a research review in the New England Journal of Medicine, Andrew Artenstein and Steven Opal argue that proprotein convertases are potentially rich targets for developing therapies.*
Most people have never heard of proprotein convertases, but the enzymes activate many proteins that are essential for life. Unfortunately, their fundamental role puts them in the middle of many processes that cause disease – not just cancer or athlerosclerosis, but both of those and Alzheimer’s and anthrax and the flu and an amazing variety of other maladies.
In a research review article appearing Dec. 29 in the New England Journal of Medicine, Andrew Artenstein, physician-in-chief in the Department of Medicine at Memorial Hospital, and Steven Opal, chief of infectious diseases at Memorial Hospital, argue that proprotein convertases (PCs) are potentially rich targets for developing therapies. Artenstein, who with Opal is on the faculty of the Warren Alpert School of Medicine, explained PCs to David Orenstein. (more…)
*Researchers coax viruses to assemble into synthetics with microstructures and properties akin to those of corneas, teeth and skin*
Using a simple, single-step process, engineers and scientists at the University of California at Berkeley recently developed a technique to direct benign, filamentous viruses called M13 phages to serve as structural building blocks for materials with a wide range of properties.
By controlling the physical environment alone, the researchers caused the viruses to self-assemble into hierarchically organized thin-film structures, with complexity that ranged from simple ridges, to wavy, chiral strands, to truly sophisticated patterns of overlapping strings of material–results that may also shed light on the self-assembly of biological tissues in nature. (more…)
*Microsoft has partnered with the University of Washington’s Baker Laboratory to help scientists supercharge the computing power of their protein folding research with Windows Azure. Helping scientists get faster results could mean speeding up cures for Alzheimer’s, cancers, salmonella, and malaria.*
REDMOND, Wash. – June 14, 2011 – Cloud computing is helping biologists uncloud one of nature’s biggest mysteries: proteins.
Microsoft has partnered with the University of Washington’s Baker Laboratory, one of the world’s top computational biology labs, to give scientists access to some high-caliber computing power. That, in turn, helps them explore and understand proteins, which could eventually lead to thwarting everything from Alzheimer’s to Malaria, and from cancer to salmonella. (more…)
GAINESVILLE, Fla. — The difficult task of sorting and counting prized stem cells and their cancer-causing cousins has long frustrated scientists looking for new ways to help people who have progressive diseases.
But in a development likely to delight math teachers, University of Floridaresearchers have devised a series of mathematical steps that accomplishes what the most powerful microscopes, high-throughput screening systems and protein assays have failed to do — assess how rapidly stem cells and their malignant, stemlike alter egos increase their numbers. (more…)
