cancers – Shamskm: A site to exchange knowledge and solutions

New research sheds light on role of HPV in head and neck cancers

By Guest PostOctober 14, 2016Healthankur chakravarthy, cancers, cervical cancer, head, hpv, hpv cancers, human papillomavirus, immune systems, neck, oropharyngeal cancers, tim fenton, tonsil cancers, tumour development

Human Papillomavirus (HPV) drives a greater number of head and neck cancers than previously thought, finds new research from UCL and the University of Southampton. (more…)

Scientists map elusive 3-D structure of telomerase enzyme, key actor in cancer, aging

By Guest PostApril 26, 2013Healthbreakthrough, cancer cells, cancer fighting drug, cancer progression, cancers, function, jiansen jiang, juli feigon, masterpiece, nobel prize, telomerase enzyme, telomerase enzyme complex, tetrahymena thermophila, three dimensional structure, uc berkeley, ucla, visual map, z hong zhou

Like finally seeing all the gears of a watch and how they work together, researchers from UCLA and UC Berkeley have, for the first time ever, solved the puzzle of how the various components of an entire telomerase enzyme complex fit together and function in a three-dimensional structure.

The creation of the first complete visual map of the telomerase enzyme, which is known to play a significant role in aging and most cancers, represents a breakthrough that could open up a host of new approaches to fighting disease, the researchers said. (more…)

New Details on the Molecular Machinery of Cancer

By Guest PostFebruary 17, 2013Scienceactivation, adam smith, addition of phosphate, anton arkhipov, autophosphorylation, berkeley lab, cancer, cancer therapies, cancers, cell surface protein, cellular functions, computational modeling, egf ligand, egfr, epidermal growth factor, fluorescence spectroscopy, gene, immune system, jay groves, john kuriyan, ligand induced dimerization, living cells, molecular machinery, nicholas endres, nuclear magnetic resonance, photon, post translational process, protein activation, quantitative approach, quantitative biology techniques, rahul das, receptor, receptor tyrosine kinases, single compound molecule, specific proteins, t-cell receptors, time resolved, uc, university of california

Berkeley Lab Researchers Resolve EGFR Activation Mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)

Mutant Gene Responsible for Pigeons’ Head Crests

By Guest PostFebruary 5, 2013Nature, Scienceanna vickery, bgi shenzhen, cancers, columba livia, elizabethan collar, ephrin receptor b2, eric domyan, feral pigeons kinship, gene affects, gene named ephb2, genes in humans, genetic blueprint, george gilchrist, human genome, mark yandell, michael campbell, mutant gene, pigeon embryos, prostate cancer, reference genome, sydney stringham, zev kronenberg

Decoded genome reveals secrets of pigeon traits and origins

Scientists have decoded the genetic blueprint of the rock pigeon, unlocking secrets about pigeons’ Middle East origins, feral pigeons’ kinship with escaped racing birds and how mutations give pigeons traits like feather head crests.

“Birds are a huge part of life on Earth, but we know surprisingly little about their genetics,” says Michael Shapiro, one of the study’s two principal authors and a biologist at the University of Utah. (more…)

Editor’s Picks: Turning Futuristic Visions into Reality

By Guest PostJanuary 3, 2012Technology3d, alzheimer, avatar kinect projects, baker laboratory, breakthroughs at microsoft, cancers, catwalk, crippling diseases, education and technology, futuristic scenarios, kinect for xbox 360, laptop, magic pushes, malaria, microsoft duo breaks, microsoft home, natural user interfaces, new year, protein mystery, salmonella, steve clayton, the printing dress, university of washington, virtual world, windows azure, your living room

*As we begin the New Year, a look at some of the stories of futuristic scenarios brought to life in 2011, plus developments that promise dramatic improvements in the near future.*

REDMOND, Wash. – Jan. 3, 2012 – From revolutionizing the way we interact with computers to developing tools to speed development of cures for crippling diseases, 2011 was a year of forward-thinking breakthroughs at Microsoft. See some of the innovations introduced in 2011 and how Microsoft is working to take new technologies from the lab to the living room. (more…)

Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them

By Guest PostDecember 18, 2011Scienceanti cancer therapies, apoptosis, biology and metabolism, cancers, cell death, cell division, chemotherapy, chromosome transmission, combination therapy, computational analyses, daughter cells, DNA, drug taxol, dynamic structure, formation of a tumor, function, genetic screen, jorge torres, kinesin like protein, malignant cells, mitosis, mitotic spindle, molecular motor, normal cells, novel strategy, protein, spindle function, stard9, toxic

Suppressing a newly identified protein involved in regulating cell division could be a novel strategy for fighting certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

During the five-year study, designed to seek new targets for anti-cancer therapies, researchers discovered that depleting the protein, called STARD9, also helped the commonly used chemotherapy drug Taxol work more effectively against certain cancers. (more…)

Researchers Study Toenails as Marker for Arsenic Exposure

By Guest PostDecember 7, 2011Environment, Sciencearsenic, arsenic concentration, biomarkers, cancers, chronic diseases, drinking water, exposure, food and water, health risks, human toenails, mary kay orourke, miranda loh, rocks, seafood, university of arizona, walter klimecki

*UA scientists have teamed up to study the relationship between arsenic in human toenails and arsenic concentration in drinking water. Exposure to arsenic is associated with several chronic diseases ranging from dermatitis to various cancers.*

Scientists from the University of Arizona specializing in environmental health sciences and pharmacology and toxicology have teamed up with the help of a seed grant to study the relationship between arsenic in human toenails and arsenic concentration in drinking water.

Arsenic exposure in Arizona is a concern because of naturally occurring contamination of groundwater, said Miranda Loh, assistant professor of environmental health sciences at the UA Mel and Enid Zuckerman College of Public Health. (more…)

Scientists Unfolding Protein Mystery, Fighting Disease with Windows Azure

By Guest PostJune 14, 2011Technologyalzheimer, baker laboratory, benchmark, cancers, chris sinco, cloud computing, computational biology labs, computing power, david baker, dennis gannon, malaria, marlin eiben, Microsoft, microsoft research extreme computing group, modern diseases, needle, nikolas sgourakis, pankaj arora, protein, salmonella, search for extraterrestrial intelligence, seti, structure and behavior of proteins, university of washington, vacation, windows azure, world class researcher with a world class problem

*Microsoft has partnered with the University of Washington’s Baker Laboratory to help scientists supercharge the computing power of their protein folding research with Windows Azure. Helping scientists get faster results could mean speeding up cures for Alzheimer’s, cancers, salmonella, and malaria.*

REDMOND, Wash. – June 14, 2011 – Cloud computing is helping biologists uncloud one of nature’s biggest mysteries: proteins.

Microsoft has partnered with the University of Washington’s Baker Laboratory, one of the world’s top computational biology labs, to give scientists access to some high-caliber computing power. That, in turn, helps them explore and understand proteins, which could eventually lead to thwarting everything from Alzheimer’s to Malaria, and from cancer to salmonella. (more…)

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