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New Details on the Molecular Machinery of Cancer

By Guest PostFebruary 17, 2013Scienceactivation, adam smith, addition of phosphate, anton arkhipov, autophosphorylation, berkeley lab, cancer, cancer therapies, cancers, cell surface protein, cellular functions, computational modeling, egf ligand, egfr, epidermal growth factor, fluorescence spectroscopy, gene, immune system, jay groves, john kuriyan, ligand induced dimerization, living cells, molecular machinery, nicholas endres, nuclear magnetic resonance, photon, post translational process, protein activation, quantitative approach, quantitative biology techniques, rahul das, receptor, receptor tyrosine kinases, single compound molecule, specific proteins, t-cell receptors, time resolved, uc, university of california

Berkeley Lab Researchers Resolve EGFR Activation Mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)

A Shiny New Tool for Imaging Biomolecules

By Guest PostApril 1, 2012Sciencearrays, berkeley lab, biomolecule, cell, cell membrane, cellular signaling network, chemical signal, christopher rhodes, disease, fluorescent, foreign invader, gold bowtie nanoantennas, gold nanoantenna, gold nanoparticle, hot-spot, hsiung lin tu, immune system, intensity, jay groves, lars iversen, lynn yarris, mark schmidt, optical imaging technique, optical nanoantenna, plasmonics, protein, raman optical signal, theo lohmuller, uc, wan chen lin

*Berkeley Lab Researchers Embed Artificial Membranes with Billions of Nanoantennas for Enhanced Optical Studies*

At the heart of the immune system that protects our bodies from disease and foreign invaders is a vast and complex communications network involving millions of cells, sending and receiving chemical signals that can mean life or death. At the heart of this vast cellular signaling network are interactions between billions of proteins and other biomolecules. These interactions, in turn, are greatly influenced by the spatial patterning of signaling and receptor molecules. The ability to observe signaling spatial patterns in the immune and other cellular systems as they evolve, and to study the impact on molecular interactions and, ultimately, cellular communication, would be a critical tool in the fight against immunological and other disorders that lead to a broad range of health problems including cancer. Such a tool is now at hand. (more…)

Berkeley Lab Scientists Develop New Tool for the Study of Spatial Patterns in Living Cells

By Guest PostNovember 2, 2011Scienceartificial membranes, berkeley lab, biology is a game of nanometers, breast cancer cells, cancer and the immune system, cancer metastasis, cellular molecules, chemical signals, chemist, fluid bilayer of lipid molecules, football, game of inches, geoff o donoghue, gold nanoparticles, golden membranes, hhmi, howard hughes medical institute, impact of spatial patterns on living cells, jay groves, lawrence berkeley national laboratory, mda mb 231, michael coyle, nanoparticles, natural lipid bilayer membranes, qian xu, sara triffo, spacing of proteins, substrate of solid silica, t cell immunology, theobald lohmuller

*Golden Membranes Pave the Way for a Better Understanding of Cancer and the Immune System*

Football has often been called “a game of inches,” but biology is a game of nanometers, where spatial differences of only a few nanometers can determine the fate of a cell – whether it lives or dies, remains normal or turns cancerous. Scientists with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a new and better way to study the impact of spatial patterns on living cells.

Berkeley Lab chemist Jay Groves led a study in which artificial membranes made up of a fluid bilayer of lipid molecules were embedded with fixed arrays of gold nanoparticles to control the spacing of proteins and other cellular molecules placed on the membranes. This provided the researchers with an unprecedented opportunity to study how the spatial patterns of chemical and physical properties on membrane surfaces influence the behavior of cells. (more…)

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New Details on the Molecular Machinery of Cancer

A Shiny New Tool for Imaging Biomolecules

Berkeley Lab Scientists Develop New Tool for the Study of Spatial Patterns in Living Cells