Tag Archives: cellular functions

New Details on the Molecular Machinery of Cancer

Berkeley Lab Researchers Resolve EGFR Activation Mystery

Researchers with Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley have provided important new details into the activation of the epidermal growth factor receptor (EGFR), a cell surface protein that has been strongly linked to a large number of cancers and is a major target of cancer therapies.

“The more we understand about EGFR and the complex molecular machinery involved in the growth and proliferation of cells, the closer we will be to developing new and more effective ways to cure and treat the many different forms of cancer,” says chemist Jay Groves, one of the leaders of this research. “Through a tour-de-force of quantitative biology techniques that included cutting edge time-resolved fluorescence spectroscopy in living cells, Nuclear Magnetic Resonance, and computational modeling, we’ve determined definitively how EGFR becomes activated through to its epidermal growth factor (EGF) ligand.” (more…)

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Mastermind Steroid Found in Plants

Palo Alto, CA — Scientists have known for some time how important plant steroids called brassinosteroids are for regulating plant growth and development. But until now, they did not know how extensive their reach is. 

Now researchers, including Yu Sun and Zhi-Yong Wang at Carnegie’s Department of Plant Biology, have identified about a thousand brassinosteroid target genes, which reveal molecular links between the steroid and numerous cellular functions and other hormonal and light-activated chain reactions. The study, published in the November 16, 2010, issue of Developmental Cell, provides the first comprehensive action map for a plant hormone. The research will help accelerate basic plant science and crop research.  (more…)

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