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How Do Cells Tell Time? Scientists Develop Single-Cell Imaging to Watch the Cell Clock

By Guest PostNovember 18, 2012Science24 hour, activity, biological noise, cell, cell division, circadian clock, cyclic gene, cyclic protein, cyclical behavior, embryonic segmentation, embryonic segments, emilie delaune, gene, gene activation, life, lifespan, mesoderm, mitosis, molecular clock, muscle, nathan shih, nervous system, notch signaling pathway, oscillating pattern, oscillation, paul françois, phase, protein, sharon amacher, signal, signal reception, single cell, somites, synchronization, tissue segments, vasculature, vertebrae, visualization, visualize, zebrafish embryos

COLUMBUS, Ohio – A new way to visualize single-cell activity in living zebrafish embryos has allowed scientists to clarify how cells line up in the right place at the right time to receive signals about the next phase of their life.

Scientists developed the imaging tool in single living cells by fusing a protein defining the cells’ cyclical behavior to a yellow fluorescent protein that allows for visualization. Zebrafish embryos are already transparent, but with this closer microscopic look at the earliest stages of life, the researchers have answered two long-standing questions about how cells cooperate to form embryonic segments that later become muscle and vertebrae. (more…)

UCLA Bioengineers Discover Single Cancer Cell Can Produce Up To Five Daughter Cells

By Guest PostJuly 16, 2012Science3d mechanical environment, aneuploidy, biological process, cancer cell, cancer mitosis, chromosome, daughter cell, dino di carlo, Environment, invasive cancer, mammalian cell division, microfluidic device, microfluidic platform, mitosis, tumor environment, ucla, westbrook mcconnell weaver

Findings could aid researchers in understanding progression of disease

It’s well known in conventional biology that during the process of mammalian cell division, or mitosis, a mother cell divides equally into two daughter cells. But when it comes to cancer, say UCLA researchers, mother cells may be far more prolific.

Bioengineers at the UCLA Henry Samueli School of Engineering and Applied Science developed a platform to mechanically confine cells, simulating the in vivo three-dimensional environments in which they divide, and found that, upon confinement, cancer cells often split into three or more daughter cells.

“We hope that this platform will allow us to better understand how the 3-D mechanical environment may play a role in the progression of a benign tumor into a malignant tumor that kills,” said Dino Di Carlo, an associate professor of bioengineering at UCLA and principal investigator on the research. (more…)

Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them

By Guest PostDecember 18, 2011Scienceanti cancer therapies, apoptosis, biology and metabolism, cancers, cell death, cell division, chemotherapy, chromosome transmission, combination therapy, computational analyses, daughter cells, DNA, drug taxol, dynamic structure, formation of a tumor, function, genetic screen, jorge torres, kinesin like protein, malignant cells, mitosis, mitotic spindle, molecular motor, normal cells, novel strategy, protein, spindle function, stard9, toxic

Suppressing a newly identified protein involved in regulating cell division could be a novel strategy for fighting certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

During the five-year study, designed to seek new targets for anti-cancer therapies, researchers discovered that depleting the protein, called STARD9, also helped the commonly used chemotherapy drug Taxol work more effectively against certain cancers. (more…)

Tag Archives: mitosis

How Do Cells Tell Time? Scientists Develop Single-Cell Imaging to Watch the Cell Clock

UCLA Bioengineers Discover Single Cancer Cell Can Produce Up To Five Daughter Cells

Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them