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Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them

By Guest PostDecember 18, 2011Scienceanti cancer therapies, apoptosis, biology and metabolism, cancers, cell death, cell division, chemotherapy, chromosome transmission, combination therapy, computational analyses, daughter cells, DNA, drug taxol, dynamic structure, formation of a tumor, function, genetic screen, jorge torres, kinesin like protein, malignant cells, mitosis, mitotic spindle, molecular motor, normal cells, novel strategy, protein, spindle function, stard9, toxic

Suppressing a newly identified protein involved in regulating cell division could be a novel strategy for fighting certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

During the five-year study, designed to seek new targets for anti-cancer therapies, researchers discovered that depleting the protein, called STARD9, also helped the commonly used chemotherapy drug Taxol work more effectively against certain cancers. (more…)

U-M Researchers Identify Protein Essential for Cell Division in Blood-forming Stem Cells

By Guest PostDecember 3, 2010Scienceampk, blood-forming stem cells, cell death, cell therapies, cellular metabolism, chromosomes, daisuke nakada, daughter cells, degenerative diseases, energy production, lkb1, normal cell division, protein, protein kinase, sean morrison, stem cell biology, stem cell function, stem cells, thomas saunders, tumor suppressor

ANN ARBOR, Mich.— University of Michigan researchers have discovered that a protein known to regulate cellular metabolism is also necessary for normal cell division in blood-forming stem cells. Loss of the protein results in an abnormal number of chromosomes and a high rate of cell death.

The finding demonstrates that stem cells are metabolically different from other blood-forming cells, which can divide without the protein, Lkb1. This metabolic difference could someday be used to better control the behavior of blood-forming stem cells used in disease treatments, said Sean Morrison, director of the U-M Center for Stem Cell Biology, which is based at the Life Sciences Institute. (more…)

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Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them

U-M Researchers Identify Protein Essential for Cell Division in Blood-forming Stem Cells