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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

By Guest PostJanuary 24, 2013Scienceanna ye, cell biologist, cell death, cell division, chromosome, chromosome microtubule interactions, culture cell, daughter cell, detection pathway, error rate, flawless cell, fluorescently tag chromosomes, fruit fly tissue, function, human disease, interaction error, kinetochore microtubule interaction, kinetochore regulator, kinetochores, massachusetts amherst, microtubule filament, mitotic spindle, modulate, molecular engine, molecular glue, molecular surveillance system, pef, polar ejection force, spindle, stuart cane, syntelic attachments, thomas maresca, university

AMHERST, Mass. – Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis. (more…)

Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them

By Guest PostDecember 18, 2011Scienceanti cancer therapies, apoptosis, biology and metabolism, cancers, cell death, cell division, chemotherapy, chromosome transmission, combination therapy, computational analyses, daughter cells, DNA, drug taxol, dynamic structure, formation of a tumor, function, genetic screen, jorge torres, kinesin like protein, malignant cells, mitosis, mitotic spindle, molecular motor, normal cells, novel strategy, protein, spindle function, stard9, toxic

Suppressing a newly identified protein involved in regulating cell division could be a novel strategy for fighting certain cancers because it stops the malignant cells from dividing and causes them to die quickly, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

During the five-year study, designed to seek new targets for anti-cancer therapies, researchers discovered that depleting the protein, called STARD9, also helped the commonly used chemotherapy drug Taxol work more effectively against certain cancers. (more…)

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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

Targeting Protein Critical To Cell Division Stops Cancer Cells From Proliferating And Kills Them