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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

By Guest PostJanuary 24, 2013Scienceanna ye, cell biologist, cell death, cell division, chromosome, chromosome microtubule interactions, culture cell, daughter cell, detection pathway, error rate, flawless cell, fluorescently tag chromosomes, fruit fly tissue, function, human disease, interaction error, kinetochore microtubule interaction, kinetochore regulator, kinetochores, massachusetts amherst, microtubule filament, mitotic spindle, modulate, molecular engine, molecular glue, molecular surveillance system, pef, polar ejection force, spindle, stuart cane, syntelic attachments, thomas maresca, university

AMHERST, Mass. – Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis. (more…)

UCLA Bioengineers Discover Single Cancer Cell Can Produce Up To Five Daughter Cells

By Guest PostJuly 16, 2012Science3d mechanical environment, aneuploidy, biological process, cancer cell, cancer mitosis, chromosome, daughter cell, dino di carlo, Environment, invasive cancer, mammalian cell division, microfluidic device, microfluidic platform, mitosis, tumor environment, ucla, westbrook mcconnell weaver

Findings could aid researchers in understanding progression of disease

It’s well known in conventional biology that during the process of mammalian cell division, or mitosis, a mother cell divides equally into two daughter cells. But when it comes to cancer, say UCLA researchers, mother cells may be far more prolific.

Bioengineers at the UCLA Henry Samueli School of Engineering and Applied Science developed a platform to mechanically confine cells, simulating the in vivo three-dimensional environments in which they divide, and found that, upon confinement, cancer cells often split into three or more daughter cells.

“We hope that this platform will allow us to better understand how the 3-D mechanical environment may play a role in the progression of a benign tumor into a malignant tumor that kills,” said Dino Di Carlo, an associate professor of bioengineering at UCLA and principal investigator on the research. (more…)

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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

UCLA Bioengineers Discover Single Cancer Cell Can Produce Up To Five Daughter Cells