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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

By Guest PostJanuary 24, 2013Scienceanna ye, cell biologist, cell death, cell division, chromosome, chromosome microtubule interactions, culture cell, daughter cell, detection pathway, error rate, flawless cell, fluorescently tag chromosomes, fruit fly tissue, function, human disease, interaction error, kinetochore microtubule interaction, kinetochore regulator, kinetochores, massachusetts amherst, microtubule filament, mitotic spindle, modulate, molecular engine, molecular glue, molecular surveillance system, pef, polar ejection force, spindle, stuart cane, syntelic attachments, thomas maresca, university

AMHERST, Mass. – Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis. (more…)

Duplex-sequencing Method Could Lead to Better Cancer Detection and Treatment

By Guest PostOctober 3, 20121 commentHealthbacteria, canadian rockies, cancer cell, cancer drug, cell mutation, chain reaction, chemotherapy, christopher klein, diagnosis, dna sequencing, duplex sequencing, error rate, ethical treatment, human cancer, hypothesis, ice climbing, infect, jesse salk, last christmas, lawrence loeb, m13, michael schmitt, mutator phenotypes, nucleotides, pcr, polymerase, rare mutation, recurrent tumor, safe seqs, scott kennedy, substructure, Technology, trip, true mutation, university, virus, Washington

During an ice climbing trip to the Canadian Rockies last Christmas, two young researchers from the University of Washington, Drs. Michael Schmitt and Jesse Salk, talked about a simple but powerful idea to get better results when looking at cancer cells. If they could reduce the error rate in DNA sequencing, then researchers could better pinpoint which cells are mutating.

This improvement could lead to early diagnosis of cancer and a better treatment plan once researchers knew which cells were resistant to chemotherapy. (more…)

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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

Duplex-sequencing Method Could Lead to Better Cancer Detection and Treatment