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UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

By Guest PostJanuary 24, 2013Scienceanna ye, cell biologist, cell death, cell division, chromosome, chromosome microtubule interactions, culture cell, daughter cell, detection pathway, error rate, flawless cell, fluorescently tag chromosomes, fruit fly tissue, function, human disease, interaction error, kinetochore microtubule interaction, kinetochore regulator, kinetochores, massachusetts amherst, microtubule filament, mitotic spindle, modulate, molecular engine, molecular glue, molecular surveillance system, pef, polar ejection force, spindle, stuart cane, syntelic attachments, thomas maresca, university

AMHERST, Mass. – Studies led by cell biologist Thomas Maresca at the University of Massachusetts Amherst are revealing new details about a molecular surveillance system that helps detect and correct errors in cell division that can lead to cell death or human diseases. Findings are reported in the current issue of the Journal of Cell Biology.

The purpose of cell division is to evenly distribute the genome between two daughter cells. To achieve this, every chromosome must properly interact with a football-shaped structure called the spindle. However, interaction errors between the chromosomes and spindle during division are amazingly common, occurring in 86 to 90 percent of chromosomes, says Maresca, an expert in mitosis. (more…)

Precautions for Tick-Borne Disease Extend “Beyond Lyme”

By Guest PostSeptember 7, 2012Health, Naturealcohol, bacterial infection, blacklegged tick, disease, eeid, ehrlichia, ehrlichiosis, ellen stromdahl, fever, graham hickling, hicklings research, human bite, human biting, human disease, jean tsao, lyme disease, mice, michigan, mid atlantic, mid virginia, nymphal, pathogen, rickettsiosis, sam scheiner, star ticks, state, state university, tennessee, tick, tick bite, tick borne, united states, university, white footed, wildlife

Save the tick that bites you: it may not be the one you think

This year’s mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast.

While Lyme disease is the most common tick-borne disease in the Northeast and Upper Midwest, new research results emphasize that it is not the greatest cause for concern in most Southeastern states.

The findings are published today in a paper in the journal Zoonoses and Public Health. (more…)

New Mouse Reference Library Should Speed Gene Discoveries

By Guest PostFebruary 17, 2012Sciencecc, collaborative cross, david threadgill, francis s collins, genes, genetic information, genetic sequences, genetic variation, human disease, jackson laboratory, lab mice, manual, mice, north carolina state university, oxford university, tel aviv university

Genetic information provided by a large group of specially designed mice could pave the way to faster human health discoveries and transform the ways people battle and prevent disease.

In 15 papers published Feb. 16 in the Genetics Society of America journals Genetics and G3:Genes/Genomes/Genetics, researchers from North Carolina State University, the University of North Carolina at Chapel Hill, The Jackson Laboratory and other universities and labs across the globe highlight a new genetic resource that could aid development of more effective treatments for any number of human diseases. (more…)

MU Researchers Find New Insight into Fatal Spinal Disease

By Guest PostOctober 2, 2011Health, Scienceamyotrophic lateral sclerosis, cells, degeneration of skeletal muscles, duchenne muscular dystrophy, dysfunctions of the synapses, global neurofilament alterations, human disease, jeffrey m dale, michael garcia, motor neurons, protein deficiency, sma, spinal muscular atrophy, system, treatments for muscular dystrophy, university of missouri, virginia garcia

*Discovery could lead to treatments for muscular dystrophy and ALS*

COLUMBIA, Mo. – Researchers at the University of Missouri have identified a communication breakdown between nerves and muscles in mice that may provide new insight into the debilitating and fatal human disease known as spinal muscular atrophy (SMA).

“Critical communication occurs at the point where nerves and muscles ‘talk’ to each other. When this communication between nerves and muscles is disrupted, muscles do not work properly,” said Michael Garcia, associate professor of biological sciences in the College of Arts and Science and the Christopher S. Bond Life Sciences Center. “In this study, we found that delivery of ‘the words’ a nerve uses to communicate with muscles was disrupted before they arrived at the nerve ending.” (more…)

Tag Archives: human disease

UMass Amherst Cell Biologists Show Molecular Forces Are Key to Proper Cell Division

Precautions for Tick-Borne Disease Extend “Beyond Lyme”

New Mouse Reference Library Should Speed Gene Discoveries

MU Researchers Find New Insight into Fatal Spinal Disease