Ancient malaria patients, the anthropologist will see you now.
A Yale University scientist has developed a promising new method to identify malaria in the bone marrow of ancient human remains. It is the first time researchers have been able to establish a diagnostic, human skeletal profile for the disease, which is transmitted by mosquitoes and continues to infect millions of people a year. (more…)
Findings could lead to natural bacterial anti-infectives in food-producing plants
COLUMBIA, Mo. – When bacteria attack plants, they often inject harmful proteins into the host plants’ cells to weaken and suppress natural defenses. However, in some plants, bacteria attack once they’ve recognized the plant cells as a potential host. Now, researchers at the University of Missouri have identified and replicated the process that allows the bacteria—known mostly for attacking tomatoes—to invade its host. This discovery could lead to natural anti-infective treatments that work with food-producing plants to enhance resistance to harmful bacteria in the field. (more…)
Sequencing of harmless oral bacterium offers insights about its disease-causing relative
COLUMBUS, Ohio – Scientists have pieced together sections of DNA from 12 individual cells to sequence the genome of a bacterium known to live in healthy human mouths.
With this new data about a part of the body considered “biological dark matter,” the researchers were able to reinforce a theory that genes in a closely related bacterium could be culprits in its ability to cause severe gum disease. (more…)
MU scientists say discovery could save farmers billions and protect the environment.
COLUMBIA, Mo. — Nitrogen fertilizer costs U.S. farmers approximately $8 billion each year, and excess fertilizer can find its way into rivers and streams, damaging the delicate water systems. Now, a discovery by a team of University of Missouri researchers could be the first step toward helping crops use less nitrogen, benefitting both farmers’ bottom lines and the environment. The journal Science published the research this month.
Gary Stacey, an investigator in the MU Bond Life Sciences Center and professor of plant sciences in the College of Agriculture, Food and Natural Resources, found that crops, such as corn, are “confused” when confronted with an invasive, but beneficial, bacteria known as rhizobia bacteria. When the bacteria interact correctly with a crop, the bacteria receive some food from the plant and, simultaneously, produce nitrogen that most plants need. In his study, Stacey found that many other crops recognize the bacteria, but do not attempt to interact closely with them. (more…)
A new study shows that common mutant forms of the deadly JC polyomavirus are not responsible for the pathogen’s main attack, which causes a brain-damaging disease in immunocompromised patients called progressive multifocal leukoencephalopathy. But that finding raises the ominous question of what the mutants might be up to instead.
PROVIDENCE, R.I. [Brown University] — The JC polyomavirus is clearly opportunistic. It infects half the population but lethally destroys brain tissue only in immunocompromised patients — and it may be outright sneaky, too. Even as a new research paper allays fears that common mutant forms of the virus are the ones directly responsible for the disease’s main attack, that same finding raises new questions about what the mutants are doing instead. (more…)
Unlike most organisms, they don’t need iron, but they crave manganese
Scientists have confirmed that the pathogen that causes Lyme Disease—unlike any other known organism—can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.
To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported. Their study, published March 22, 2013, in The Journal of Biological Chemistry, may explain some mysteries about why Lyme Disease is slow-growing and hard to detect and treat. The findings also open the door to search for new therapies to thwart the bacterium by targeting manganese. (more…)
Discovery resulted from study of amphibians in ponds
The richer the assortment of amphibian species in a pond, the more protection that community of frogs, toads and salamanders has against a parasitic infection that can cause severe deformities, including the growth of extra legs.
The findings, published in a paper in this week’s issue of the journal Nature, support the idea that greater biodiversity in large-scale ecosystems, such as forests or grasslands, may also provide greater protection against diseases, including those that affect humans.
A larger number of mammal species in an area may curb cases of Lyme disease, while a larger number of bird species may slow the spread of West Nile virus. (more…)
The gut bacteria of honey bees have acquired several genes that confer resistance to tetracycline, a direct result of more than five decades of use of antibiotics by American beekeepers and a potential health hazard for bee colonies, a new study by Yale University researchers show.
The genetic analysis of the gut bacteria, which are believed to help in bees’ digestion and ability to ward off parasites, suggests changing antibiotic use by beekeepers might be one factor in the mysterious colony collapse disorder afflicting bee populations. (more…)
