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Scientists Reveal Quirky Feature of Lyme Disease Bacteria

By Guest PostApril 15, 2013Environmentantioxidant enzyme, bloodstream, borrelia burgdorferi, borrelia enzymes, cape cod, catalyze, christine vazquez, cobalt, defense mechanism, enzyme, frank gherardini, hillary clark, hormone, immune system, j daphne aguirre, james posey, jhu, johns hopkins university, liver produces hepcidin, lyme disease bacteria, mak saito, manganese, metal trafficking, metalloproteins, oceanographic institution, pathogen, pathogens of iron, proteins, shaina palmere, superoxide dismutase, university of georgia, university of texas, valeria culotta, vitamin supplements, whoi, woods hole, zinc

Unlike most organisms, they don’t need iron, but they crave manganese

Scientists have confirmed that the pathogen that causes Lyme Disease—unlike any other known organism—can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.

To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported. Their study, published March 22, 2013, in The Journal of Biological Chemistry, may explain some mysteries about why Lyme Disease is slow-growing and hard to detect and treat. The findings also open the door to search for new therapies to thwart the bacterium by targeting manganese. (more…)

Green Tea Extract Interferes with the Formation of Amyloid Plaques in Alzheimer’s Disease

By Guest PostMarch 15, 2013Healthakiko kochi, alaina detoma, alzheimer's disease, ayyalusamy ramamoorthy, benefit, bing ye, brain, brandon ruotoloa, copper, egcg, epigallocatechin 3 gallate, green tea, iron, jung suk choi, life sciences institute, metal associated amyloids, mi hee lim, molecule, neurodegenerative conditions, powerful antioxidants, sanghyun lee, specific proteins, structure centric, subramanian vivekanandan, suk joon hyung, tweak, university of michigan, zinc

ANN ARBOR — Researchers at the University of Michigan have found a new potential benefit of a molecule in green tea: preventing the misfolding of specific proteins in the brain.

The aggregation of these proteins, called metal-associated amyloids, is associated with Alzheimer’s disease and other neurodegenerative conditions. (more…)

Zinc Helps against Infection by Tapping Brakes in Immune Response

By Guest PostFebruary 13, 2013Healthaction, against infection, andrew rudawsky, animal studies, beans, bug, cell culture, charlie pyle, collateral damage, dairy products, daren knoell, excessive inflammation, fortified cereals, human monocytes, ikkb, immune response, inflammatory pathway, invading pathogen, key cells, mark wewers, ming jie liu, nf kb pathway, nuts, ohio state university, protein, shengying bao, some shellfish, sustain human life, tapping brakes, toxic levels, united states, vulnerability to infection, whole grains, zinc, zinc deficiency, zinc deficient mice, zinc supplementation, zinc transporter, zip8

COLUMBUS, Ohio – New research suggests that zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out-of-control inflammation that can be damaging and even deadly.

Scientists determined in human cell culture and animal studies that a protein lures zinc into key cells that are first-responders against infection. The zinc then interacts with a process that is vital to the fight against infection and by doing so helps balance the immune response. (more…)

Increase in Metal Concentrations in Rocky Mountain Watershed Tied to Warming Temperatures

By Guest PostSeptember 10, 2012Environmentacid rock drainage, acidity, air temperature, andrew manning, andrew todd, ard, bedrock, biologist, caitlin crouch, calcium concentration, chemical reaction, colorado, colorado boulder, continental divide, diane mcknight, ecological concern, geological survey, hypothesis, keystone, metal concentration, mineral weathering, mineralized, pennsylvania mine, permafrost, peru creek, philip verplanck, pyrite, pyrite weathering, rate, remediation effort, rocky mountain, snake river, stream, stream ecosystem, sulfide mineral, sulfuric acid, tributary, united states, university, US, usgs, water table, watershed, zinc

Warmer air temperatures since the 1980s may explain significant increases in zinc and other metal concentrations of ecological concern in a Rocky Mountain watershed, reports a new study led by the U.S. Geological Survey and the University of Colorado Boulder.

Rising concentrations of zinc and other metals in the upper Snake River just west of the Continental Divide near Keystone, Colo., may be the result of falling water tables, melting permafrost and accelerating mineral weathering rates, all driven by warmer air temperatures in the watershed. Researchers observed a fourfold increase in dissolved zinc over the last 30 years during the month of September. (more…)

Acid Rain

By Guest PostMay 4, 2012Environmentacid rain, acidic, acidity, air, basic, canopy, cape henlopen, carbonic acid, clean air act, concentration, copper, delaware rain, ecosystem, joseph scudlark, lake sediments, lead, lewes, marine studies, mercury, monitoring, nitric, organism, ph, pollutant, precipitation, rainwater, state park, sulfuric, thomas church, trace metal, zinc

UD’s long-term monitoring shows 60 percent reduction in acidity of Delaware rain

Several decades ago, precipitation in Delaware was among the most acidic in the country. Pollutants in the air reacted with rainwater to sprinkle sulfuric, nitric and carbonic acids onto the ground below, affecting crops and ecosystems statewide.

The scientific consensus is that pollution controls enacted through the Clean Air Act Amendments in the 1990s and other measures have helped decrease the acidity of rain by approximately 60 percent to less harmful levels, as reflected in data gathered nationwide and by UD researchers in Lewes, Del., as part of a longstanding study. (more…)

Zinc’s Role in the Brain

By Guest PostOctober 13, 2011Health, Sciencechemical in synaptic vesicles, duke university, long-term potentiation, neuroscience, stores neurotransmitters, the role of zinc in the brain, university of toronto scarborough (utsc), xiao-an zhang, zinc, zinc’s function, zinc’s role in the brain, zx1

*Research gives insight into 50-year-old mystery – zinc important for learning and memory

TORONTO, ON – Zinc plays a critical role in regulating how neurons communicate with one another, and could affect how memories form and how we learn. The new research, in the current issue of Neuron, was authored by Xiao-an Zhang, now a chemistry professor at the University of Toronto Scarborough (UTSC), and colleagues at MIT and Duke University.

Researchers have been trying to pin down the role of zinc in the brain for more than fifty years, ever since scientists found high concentrations of the chemical in synaptic vesicles, a portion of the neuron that stores neurotransmitters. But it was hard to determine just what zinc’s function was. (more…)

How Tattoos ‘Move’ With Age

By Guest PostJune 6, 2011Culture, Sciencecadmium, dyes, fibroblast cells, fluid mechanics, ian eames, initial immune response, ink particles, iron, lead, lymphatic system, mathematical framework, mathematical model, mathematics today, mercury, nickel, skin, surface of the skin, suspension of particles, tattoos, white blood cells, zinc

The dyes which are injected into the skin to create tattoos move with time – permanently altering the look of a given design. In this month’s Mathematics Today Dr Ian Eames, a Reader in Fluid Mechanics at UCL, publishes a mathematical model enabling us to estimate the movement of these ink particles and predict how specific tattoo designs will look several years in the future.

“Tattoos are incredibly popular worldwide with more than a third of 18-25 year olds in the USA sporting at least one design,” says Dr Eames. “A great deal of work has already been done on the short term fate of ink particles in the skin, tracking them over periods of just a few months – but much less is known about how these particles move over longer periods of time. (more…)

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