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Study reveals workings of immune response to deadly fungal infections

By Guest PostFebruary 11, 2017Healthangel byrd, candida albicans, courtney johnson, extracellular matrix, fungal infections, fungal pathogens, immune response, infected tissue, jonathan reichner, neutrophils attack, sticky dna strands, tendrilous hyphae, xian obrien

Now that scientists understand what triggers key steps in the immune response to menacing fungi such as Candida albicans, they hope to develop ways to make it work better.

PROVIDENCE, R.I. [Brown University] — Every year, fungal infections threaten thousands of patients — from those with depressed immune systems to others who have had surgeries or devices such as catheters implanted. Moreover, some anti-fungal medications are beginning to lose their power. (more…)

Making Old Lungs Look New Again

By Guest PostOctober 15, 2014Healthalten ddr sammlung, atlantic city, bacteria, can li, chris mclinden, cytokines, Environment, hamish sharma, heart disease, immune response, immune system cells, infection, lung inflammation, macrophages, michael baales, most, pro inflammatory proteins, sabine gaudzinski windheuser, scientific photo, tb, tiefsee, tischlein deck dich, top source, type 2 diabetes, tyson vs spinks

Animal research suggests ibuprofen can reduce lung inflammation in elderly

COLUMBUS, Ohio – New research shows that the lungs become more inflammatory with age and that ibuprofen can lower that inflammation.

In fact, immune cells from old mouse lungs fought tuberculosis bacteria as effectively as cells from young mice after lung inflammation was reduced by ibuprofen. The ibuprofen had no effect on the immune response to TB in young mice. (more…)

Gene therapy leads to robust improvements in animal model of fatal muscle disease

By Guest PostJanuary 26, 2014Healthaav gene therapy, adenovirus vector, animal model, anna buj bello, beggs groups, brian donohue, clare mclean, dog, dog family tree, family dog bella, fatal muscle disease, france, gene therapy, genethon, human nutrition, immune response, martin k childers, mouse model, mtm1 gene, mtm1 gene mutation, robert w grange, toxic, university of washington, vector, xlinked myotubular myopathy

Preclinical studies show that gene therapy can improve muscle strength in small- and large-animal models of a fatal congenital childhood disease know as X-linked myotubular myopathy.

The findings, appearing as the cover story in the January 22, 2014 issue of Science Translational Medicine, also demonstrate the feasibility of future clinical trials of gene therapy for this devastating disease. (more…)

Nature Medicine

By Guest PostJanuary 14, 2014Health, Sciencecd4 t cells, fabian cardozo, hiv, hiv reservoir, hiv treatments, hiv virus replication, immune response, infected cell, mathias lichterfeld, memory tcells, metabolic pathways, mgh, nature medicine, quiescent infections, role, ryan zurakowski, stem cell, stop the infection, t cell type, t cells, therapy, thymus gland, tscm, type of lymphocyte, university of delaware, white blood cell

Engineering professor co-authors Nature Medicine paper on HIV

Ryan Zurakowski, assistant professor of electrical and computer engineering at the University of Delaware, is co-author of a paper appearing in Nature Medicine on Jan. 12 highlighting the role of T-cells in HIV.

The paper, titled “HIV-1 Persistence in CD4+ T-Cells with Stem Cell-Like Properties,” provides evidence that a particular T-cell type may help researchers better understand why HIV can persist despite treatment. (more…)

Effects of Climate Change on West Nile Virus

By Guest PostSeptember 11, 2013Environment, Healthandrew comrie, brain, canada, cdc, changes in climate, climate change, climate change models, climate-driven, cory morin, culex quinquefasciatus, effect, encephalitis, immune response, infectious cycle, inflammation, meningitis, mosquito population model, mosquito populations, North America, precipitation, southern us, species, temperature, united states, university of arizona, virus carrying mosquitoes, west nile vector, west nile virus

A study projects how climate change may affect virus-carrying mosquitoes across the southern U.S. Changes are expected to vary with region, and the southern states should see a trend toward longer seasons of mosquito activity and smaller midsummer mosquito populations

The varied influence of climate change on temperature and precipitation may have an equally wide-ranging effect on the spread of West Nile virus, suggesting that public health efforts to control the virus will need to take a local rather than global perspective, according to a study published this week in the scientific journal Proceedings of the National Academy of Sciences. (more…)

Tactics of new Middle East virus suggest treating by altering lung cells’ response to infection

By Guest PostJune 7, 2013Healthacute, antiviral reaction, China, DNA, Environment, flu virus, h7n9 influenza virus, host, human coronavirus, human coronavirus emc, immune response, killing the virus, laurence josset, lisa e gralinski, lung cell gene, lung cells, mbio, michael g katze, middle east virus, pathogen interactions, respiratory syndrome virus, response to infection, rna, sars, sudhakar agnihothram, tactics, university of washington, vineet d menachery, virologist

A new virus that causes severe breathing distress and kidney failure elicits a distinctive airway cell response to allow it to multiply. Scientists studying the Human Coronavirus-Erasmus Medical Center, which first appeared April 2012 in the Middle East, have discovered helpful details about its stronghold tactics.

Their findings predict that certain currently available compounds might treat the infection. These could act not by killing the virus directly but by keeping lung cells from being forced to create a hospitable environment for the virus to reproduce. The researchers caution that their lab and computer predictions would need to be tested to see if the drugs work clinically. (more…)

Zinc Helps against Infection by Tapping Brakes in Immune Response

By Guest PostFebruary 13, 2013Healthaction, against infection, andrew rudawsky, animal studies, beans, bug, cell culture, charlie pyle, collateral damage, dairy products, daren knoell, excessive inflammation, fortified cereals, human monocytes, ikkb, immune response, inflammatory pathway, invading pathogen, key cells, mark wewers, ming jie liu, nf kb pathway, nuts, ohio state university, protein, shengying bao, some shellfish, sustain human life, tapping brakes, toxic levels, united states, vulnerability to infection, whole grains, zinc, zinc deficiency, zinc deficient mice, zinc supplementation, zinc transporter, zip8

COLUMBUS, Ohio – New research suggests that zinc helps control infections by gently tapping the brakes on the immune response in a way that prevents out-of-control inflammation that can be damaging and even deadly.

Scientists determined in human cell culture and animal studies that a protein lures zinc into key cells that are first-responders against infection. The zinc then interacts with a process that is vital to the fight against infection and by doing so helps balance the immune response. (more…)

Countering Brain Chemical Could Prevent Suicides

By Guest PostDecember 14, 2012Healthamino acid, anesthetic ketamine, anti glutamate drugs, anti inflammatory drugs, brain, causes of depression, chemical, glutamate, glutamate activity, glutamate signaling, grand rapids, immune response, inflammation, inhibit, lena brundin, mechanism of disease, michigan state university, nerve cells, neurotransmitter, preventing suicide, quinolinic acid, risk factor, serotonin, signals, spinal fluid, suicidal behavior

Researchers have found the first proof that a chemical in the brain called glutamate is linked to suicidal behavior, offering new hope for efforts to prevent people from taking their own lives.

Writing in the journal Neuropsychopharmacology, Michigan State University’s Lena Brundin and an international team of co-investigators present the first evidence that glutamate is more active in the brains of people who attempt suicide. Glutamate is an amino acid that sends signals between nerve cells and has long been a suspect in the search for chemical causes of depression. (more…)

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