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Modified Vaccine Shows Promise in Preventing Malaria

EAST LANSING, Mich. — Continuing a global effort to prevent malaria infections, Michigan State University researchers have created a new malaria vaccine – one that combines the use of a disabled cold virus with an immune system-stimulating gene – that appears to increase the immune response against the parasite that causes the deadly disease.

At the same time, the group led by Andrea Amalfitano of the College of Osteopathic Medicine also discovered another immune-system stimulating agent – created at MSU and which has been successful in improving immune responses in vaccines for diseases such as HIV – paradoxically made for a less effective malaria vaccine. (more…)

The Genetics of Self-Incompatibility

By Guest PostNovember 6, 2010Nature, Scienceantigens, female, fertilization, genes, genetic, immune response, inbreeding, male, offspring, organism, petunia, petunia pistil, petunia pollen, plant, pollen, proteins, rna, rna-destroying enzyme, seiji takayama, sexual organs, t-cell receptors, teh-hui kao

*Petunias show that the mechanisms behind inbreeding prevention are similar to immune response*

About the image: The female part of the petunia flower secretes an enzyme that is designed to deter pollen tube growth, thereby preventing fertilization. However, in the cases that the pollen has come from a genetically different plant, the pollen produces its own protein that combats the pistil’s enzyme. With the enzyme out of the way, the pollen tube can keep growing and fertilization can occur. Image credit: Zina Deretsky, National Science Foundation

Inbreeding is a bad strategy for any organism, producing weak and problematic offspring. So imagine the challenge of inbreeding prevention in a plant where male and female sexual organs grow right next to each other! Such is the genetic conundrum faced by the petunia. (more…)

Tag Archives: immune response

Modified Vaccine Shows Promise in Preventing Malaria

The Genetics of Self-Incompatibility