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New Insights into How Genetic Differences among Individuals Influence Breast Cancer Risk from Low-Dose Radiation

By Guest PostOctober 17, 2012Health, Scienceandy wyrobek, antoine snijders, berkeley lab, breast cancer, cancer risk, cellular, cellular proliferation, chemical therapy, ct scan, department, dna repair, energy, gene, genetic makeup, gland cancer, immune response, ionizing radiation, joe gray, low dose, mammary tissue, mechanism, mice, non radiation, radiotherapy, resistance, risk, scientist, strain, survival outcome, therapy, tissue mechanism, tissue stress, woman

Berkeley Lab research could lead to new ways to ID women who have higher risk of breast cancer from low-dose radiation

Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified tissue mechanisms that may influence a woman’s susceptibility or resistance to breast cancer after exposure to low-dose ionizing radiation, such as the levels used in full-body CT scans and radiotherapy.

The research could lead to new ways to identify women who have higher or lower risks of breast cancer from low-dose radiation. Such a predictive tool could help guide the treatment of cancer patients who may be better served by non-radiation therapies. (more…)

Cracking the Oyster’s Code

By Guest PostSeptember 23, 2012Natureair exposure, analysis, atlantic, bioengineering project, cell, death, delaware, DNA, dynamic environment, evolution, factor, genetic code, genome, genome project, gulf coast, heat shock, immune response, oyster, pacific oyster, parasites, pathogen, patrick m gaffney, stress, survival, temperature fluctuation, toxic chemical, toxic metal, university

International team of scientists finds adaptations to stress in oyster genome

When it comes to stress, oysters know how to deal. The tough-shelled mollusks can survive temperature fluctuations, toxic metals and exposure to air, and a new study of their genetic makeup is helping to explain how.

An international team of scientists, including the University of Delaware’s Patrick M. Gaffney, professor of marine biosciences, sequenced the genome of the Pacific oyster, Crassostrea gigas, in a Nature paper published on Sept. 19. (more…)

Researchers Come a Step Closer to Finding HIV Vaccine

By Guest PostSeptember 18, 2012Healthgenetic signature, heterosexual, hiv, hiv 1 vaccine, hiv research, immune response, men, morgane rolland, program, protein, strain, us military, v2 region, women

Scientists used genetic sequencing to discover that the vaccine used in the RV144 HIV vaccine trial, involving 16,000 men and women in Thailand, did offer some protection against certain HIV viruses. The results were published Sept. 10 in the online edition of Nature.

James Mullins, UW professor of microbiology, medicine and laboratory medicine, leads one of the two laboratories that did genetic analyses of the virus. He said the study proved that an HIV vaccine is within reach. (more…)

People with Allergies May Have Lower Risk of Brain Tumors

By Guest PostAugust 6, 2012Healthbrain tumor risk, glioma diagnosis, immune response, people with allergies, respiratory allergies, tumor risk

COLUMBUS, Ohio – New research adds to the growing body of evidence suggesting that there’s a link between allergies and reduced risk of a serious type of cancer that starts in the brain. This study suggests the reduced risk is stronger among women than men, although men with certain allergy profiles also have a lower tumor risk. (more…)

Modified Vaccine Shows Promise in Preventing Malaria

By Guest PostSeptember 29, 2011Health, Scienceandrea amalfitano, barnett rosenberg, circumsporozoite protein, csp, deadly disease, eat 2, gene, gene adjuvants, global effort to prevent malaria infections, hiv, immune response, immune system stimulating gene, key role, malaria parasite, malaria vaccine, michigan state university, nathaniel j schuldt, protein, rea, us army, vaccine, virus, yasser a aldhamen

EAST LANSING, Mich. — Continuing a global effort to prevent malaria infections, Michigan State University researchers have created a new malaria vaccine – one that combines the use of a disabled cold virus with an immune system-stimulating gene – that appears to increase the immune response against the parasite that causes the deadly disease.

At the same time, the group led by Andrea Amalfitano of the College of Osteopathic Medicine also discovered another immune-system stimulating agent – created at MSU and which has been successful in improving immune responses in vaccines for diseases such as HIV – paradoxically made for a less effective malaria vaccine. (more…)

The Genetics of Self-Incompatibility

By Guest PostNovember 6, 2010Nature, Scienceantigens, female, fertilization, genes, genetic, immune response, inbreeding, male, offspring, organism, petunia, petunia pistil, petunia pollen, plant, pollen, proteins, rna, rna-destroying enzyme, seiji takayama, sexual organs, t-cell receptors, teh-hui kao

*Petunias show that the mechanisms behind inbreeding prevention are similar to immune response*

About the image: The female part of the petunia flower secretes an enzyme that is designed to deter pollen tube growth, thereby preventing fertilization. However, in the cases that the pollen has come from a genetically different plant, the pollen produces its own protein that combats the pistil’s enzyme. With the enzyme out of the way, the pollen tube can keep growing and fertilization can occur. Image credit: Zina Deretsky, National Science Foundation

Inbreeding is a bad strategy for any organism, producing weak and problematic offspring. So imagine the challenge of inbreeding prevention in a plant where male and female sexual organs grow right next to each other! Such is the genetic conundrum faced by the petunia. (more…)

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