Tag Archives: genetic code

Great ape genetic diversity catalog frames primate evolution and future conservation

A model of great ape history during the past 15 million years has been fashioned through the study of genetic variation in a large panel of humans, chimpanzees, gorillas and orangutans.  The catalog of great ape genetic diversity, the most comprehensive ever, elucidates the evolution and population histories of great apes from Africa and Indonesia. The resource will likely also aid in current and future conservation efforts which strive to preserve natural genetic diversity in populations.

More than 75 scientists and wildlife conservationists from around the world assisted the genetic analysis of 79 wild and captive-born great apes. They represent all six great ape species: chimpanzee, bonobo, Sumatran orangutan, Bornean orangutan, eastern gorilla, and western lowland gorilla, and seven subspecies.  Nine human genomes were included in the sampling. (more…)

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Genomic Detectives Crack the Case of the Missing Heritability

Despite years of research, the genetic factors behind many human diseases and characteristics remain unknown. The inability to find the complete genetic causes of family traits such as height or the risk of type 2 diabetes has been called the “missing heritability” problem.

A new study by Princeton University researchers, however, suggests that missing heritability may not be missing after all — at least not in yeast cells, which the researchers used as a model for studying the problem. Published in the journal Nature, the results suggest that heritability in humans may be hidden due only to the limitations of modern research tools, but could be discovered if scientists know where (and how) to look. (more…)

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Nanopore Sequencing: DNA Prefers to Dive Head First into Nanopores

In the 1960s, Nobel laureate Pierre-Gilles de Gennes postulated that someday researchers could test his theories of polymer networks by observing single molecules. Researchers at Brown observed single molecules of DNA being drawn through nanopores by electrical current and figured out why they most often travel head first.

PROVIDENCE, R.I. [Brown University] — If you want to understand a novel, it helps to start from the beginning rather than trying to pick up the plot from somewhere in the middle. The same goes for analyzing a strand of DNA. The best way to make sense of it is to look at it head to tail.

Luckily, according to a new study by physicists at Brown University, DNA molecules have a convenient tendency to cooperate. (more…)

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Alex Papan: “Friday……fry THE day”

Alex took some free days – five days plus two weekends. He is not sure whether he will count this Friday too. He left office at thirty past ten. Boss didn’t say anything. Alex always makes some extra hours in week to keep it for Friday’s. Naahhh….intelligent…….Alex laughed…

Although it’s just noon, but Alex thought it’s time for his favorite bier – Krombacher. Why he likes the brand……he doesn’t know. Once Alessandra asked him……..and it might be slip of tongue……Krombacher came out to his world. He sighed. How fast time flies! Nothing went fine with her. There were troubles everywhere, in everything. He should have consulted an astrologer. Love’s there, troubles too. But why? This co-existence? (more…)

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Cracking the Oyster’s Code

International team of scientists finds adaptations to stress in oyster genome

When it comes to stress, oysters know how to deal. The tough-shelled mollusks can survive temperature fluctuations, toxic metals and exposure to air, and a new study of their genetic makeup is helping to explain how.

An international team of scientists, including the University of Delaware’s Patrick M. Gaffney, professor of marine biosciences, sequenced the genome of the Pacific oyster, Crassostrea gigas, in a Nature paper published on Sept. 19. (more…)

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More Than Matters of the Heart

A team of researchers, including Mary-Frances O’Connor at the UA, has found a genetic variability linked to stress and inflammation that may impact the health of some widows and widowers.

The death of a spouse can be one of life’s most distressing events, and for many years bereavement researchers have noted increased mortality risk in some widows and widowers. This has been called the “widowhood effect.”

Researchers at the University of California, Los Angeles, the Hannover Medical School in Germany, the University of Ulm in Germany and the University of Arizona have found a genetic variability linked to stress and inflammation that may impact the health of some widows and widowers. (more…)

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UCLA Scientists Discover How Key Enzyme Involved in Aging, Cancer Assembles

UCLA biochemists have mapped the structure of a key protein–RNA complex that is required for the assembly of telomerase, an enzyme important in both cancer and aging.

The researchers found that a region at the end of the p65 protein that includes a flexible tail is responsible for bending telomerase’s RNA backbone in order to create a scaffold for the assembly of other protein building blocks. Understanding this protein, which is found in a type of single-celled organism that lives in fresh water ponds, may help researchers predict the function of similar proteins in humans and other organisms. (more…)

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Timely Ends: Telomere Length in Early Life Predicts Lifespan

New research by a team from the Universities of Glasgow and Exeter shows that a good indicator of how long individuals will live can be obtained from early in life using the length of specialised pieces of DNA called telomeres.

Telomeres occur at the ends of the chromosomes, which contain our genetic code.

They function a bit like the plastic caps at the end of shoelaces by marking the chromosome ends and protecting them from various process that gradually cause the ends to be worn away. This method of DNA protection is the same for most animals and plants, including humans, and the eventual loss of the telomere cap is known to cause cells to malfunction. This study is the first in which telomere length has been measured repeatedly from early in life of an individual and then for the rest of their natural lives. The results show that telomere length in early life is strongly predictive of lifespan. (more…)

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