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Nanopore Sequencing: DNA Prefers to Dive Head First into Nanopores

By Guest PostJanuary 18, 2013Sciencebertrand duplantier, de gennes, derek stein, dna molecules, gelatin molecules, genetic code, mirna mihovilovic, molecule entropy, molecule zipping, molecules of dna, nanopore sequencing, nanopores, nick hagerty, nucleotide base, pierre gilles, polymer network, sensor, solid state nanopores, theory of jello

In the 1960s, Nobel laureate Pierre-Gilles de Gennes postulated that someday researchers could test his theories of polymer networks by observing single molecules. Researchers at Brown observed single molecules of DNA being drawn through nanopores by electrical current and figured out why they most often travel head first.

PROVIDENCE, R.I. [Brown University] — If you want to understand a novel, it helps to start from the beginning rather than trying to pick up the plot from somewhere in the middle. The same goes for analyzing a strand of DNA. The best way to make sense of it is to look at it head to tail.

Luckily, according to a new study by physicists at Brown University, DNA molecules have a convenient tendency to cooperate. (more…)

Graphene and DNA

‘Wonder material’ may hold key to fast, inexpensive genetic sequencing

Look at the tip of that old pencil in your desk drawer, and what you’ll see are layers of graphite that are thousands of atoms thick. Use the pencil to draw a line on a piece of paper, and the mark you’ll see on the page is made up of hundreds of one-atom layers.

But when scientists found a way—using, essentially, a piece of ordinary sticky tape—to peel off a layer of graphite that was just a single atom thick, they called the two-dimensional material graphene and, in 2010, won the Nobel Prize in physics for the discovery. (more…)

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Nanopore Sequencing: DNA Prefers to Dive Head First into Nanopores

Graphene and DNA