genetic variation – Shamskm: A site to exchange knowledge and solutions

Link between low vitamin D blood levels and heart disease varies by race

By Guest PostJuly 25, 2013Health25 hydroxyvitamin, blacks, blood levels, by race, cardiovascular events, cassianne robinson cohen, chinese, coronary heart disease, gene variations, genetic variation, heart disease, hispanics, ian deboer, jama, kidney disease, kidney research institute, leila gray, low vitamin d, mesa, metabolism, michael lauer, multi ethnic, risk factors, study group, united states, university of washington, vitamin d activation, vitamin d levels, whites

Low vitamin D blood levels are linked to greater risk of heart disease in whites and Chinese, but not in blacks and Hispanics, according to a study appearing this week in JAMA, the Journal of the American Medical Association.

Growing evidence has suggested that low blood levels of 25-hydroxyvitamin are associated with higher risk of developing coronary heart disease among whites. Few of these studies included substantial numbers of people from other races. (more…)

Great ape genetic diversity catalog frames primate evolution and future conservation

By Guest PostJuly 5, 2013Natureafrica, aids, ashmael, barcelona, behavioral disorders, belinga, bornean orangutan, chimpanzees, cognitive, dna segment, eastern gorilla, evan eichler, future conservation, genetic code, genetic diversity catalog, genetic variation, genome sciences, geographic isolation, gorillas, great ape, great ape species, humans, indonesia, javier prado martinez, map, migration, model, orangutans, origin of hiv, peter sudmant, primate evolution, seattle, simian immunodeficiency virus, siv, spain, suzie a, tomas marques bonet, universitat pompeu fabra, university of washington, virus, western lowland gorilla

A model of great ape history during the past 15 million years has been fashioned through the study of genetic variation in a large panel of humans, chimpanzees, gorillas and orangutans. The catalog of great ape genetic diversity, the most comprehensive ever, elucidates the evolution and population histories of great apes from Africa and Indonesia. The resource will likely also aid in current and future conservation efforts which strive to preserve natural genetic diversity in populations.

More than 75 scientists and wildlife conservationists from around the world assisted the genetic analysis of 79 wild and captive-born great apes. They represent all six great ape species: chimpanzee, bonobo, Sumatran orangutan, Bornean orangutan, eastern gorilla, and western lowland gorilla, and seven subspecies. Nine human genomes were included in the sampling. (more…)

More Than Matters of the Heart

By Guest PostJuly 18, 2012Health, Sciencecause of death, chronic disease, complicated grief scale, death, genetic code, genetic variation, Germany, hannover medical school, Health, inflammation, journal brain, los angeles, mary frances oconnor, pro inflammatory, spouse, stress, symptoms of loss, university of arizona, university of california, university of ulm, widowhood effect

A team of researchers, including Mary-Frances O’Connor at the UA, has found a genetic variability linked to stress and inflammation that may impact the health of some widows and widowers.

The death of a spouse can be one of life’s most distressing events, and for many years bereavement researchers have noted increased mortality risk in some widows and widowers. This has been called the “widowhood effect.”

Researchers at the University of California, Los Angeles, the Hannover Medical School in Germany, the University of Ulm in Germany and the University of Arizona have found a genetic variability linked to stress and inflammation that may impact the health of some widows and widowers. (more…)

Cancer Genes Differ in Different Parts of a Tumour

By Guest PostMarch 17, 2012Health, Sciencebiomarkers, biopsies, biopsy, cancer cell, cancer treatment, charles swanton, gene faults, genetic fault, genetic landscape, genetic variation, genome, genome sequencing technology, james larkin, kidney cancer, kidney tumours, lesley walker, molecular change, mutation, primary tumour, subtype, theory, tree of life, tumour, ubiquitous mutations

Taking a sample from just one part of a tumour may not give a full picture of its‘genetic landscape’, according to a study published in the New England Journal of Medicine.

The findings could help explain why attempts at using single biopsies to identify biomarkers to which personalised cancer treatments can be targeted have not been more successful. (more…)

New Mouse Reference Library Should Speed Gene Discoveries

By Guest PostFebruary 17, 2012Sciencecc, collaborative cross, david threadgill, francis s collins, genes, genetic information, genetic sequences, genetic variation, human disease, jackson laboratory, lab mice, manual, mice, north carolina state university, oxford university, tel aviv university

Genetic information provided by a large group of specially designed mice could pave the way to faster human health discoveries and transform the ways people battle and prevent disease.

In 15 papers published Feb. 16 in the Genetics Society of America journals Genetics and G3:Genes/Genomes/Genetics, researchers from North Carolina State University, the University of North Carolina at Chapel Hill, The Jackson Laboratory and other universities and labs across the globe highlight a new genetic resource that could aid development of more effective treatments for any number of human diseases. (more…)

‘Social Relationships in Animals Have a Genetic Basis’

By Guest PostDecember 8, 20102 commentsScienceamanda lea, animals, colorado, daniel t blumstein, female marmots, genetic, genetic component, genetic variation, human behavior, interactions, marmots, non-human population, rocky mountains, social behavior, social network trait, squirrels, tolerate aggression

The ability to tolerate aggression is partly genetic, UCLA life scientists report in the first study to demonstrate a genetic component to a social network trait in a non-human population.

“The ability to tolerate aggression is passed on across generations; there is genetic variation in the ability to tolerate aggression,” said the study co-author Daniel T. Blumstein, professor and chair of ecology and evolutionary biology at UCLA.

Blumstein, a leader in the field of applying social network statistics to animals, and his colleagues studied four groups of yellow-bellied marmots, which are related to squirrels, over six years in the Rocky Mountains of Colorado. Each group included 15 to 30 marmots. (more…)

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