A study by UCLA researchers reveals the cellular basis for how the hormone estrogen protects against damage to the central nervous system in women with multiple sclerosis, or MS. The researchers found that estrogen treatment exerts positive effects on two types of cells during disease — immune cells in the brain as well as cells called oligodendrocytes. (more…)
Tag Archives: mice
Sensitive Toxicity Test Used Sugars in Doses Like What We Eat
When University of Utah biologists fed mice sugar in doses proportional to what many people eat, the fructose-glucose mixture found in high-fructose corn syrup was more toxic than sucrose or table sugar, reducing both the reproduction and lifespan of female rodents. (more…)
As injections or pills, drug inhibits an enzyme active in many cancer types
A new drug, known as OTS964, can eradicate aggressive human lung cancers transplanted into mice, according to a new report. The drug, given as a pill or by injection, inhibits the action of a protein that is overproduced by several tumor types, including lung and breast, but is rarely expressed in healthy adult tissues. Without this protein, cancer cells begin the cell-division process but fail to complete it and die. (more…)
A man with almost no hair on his body has grown a full head of it after a novel treatment by doctors at Yale University.
There is currently no cure or long-term treatment for alopecia universalis, the disease that left the 25-year-old patient bare of hair. This is the first reported case of a successful targeted treatment for the rare, highly visible disease. (more…)
Taichi Suzuki, an Evolutionary Biologist, is currently involved in PhD program in Integrative Biology at the University of California Berkeley. He received his Bachelor’s degree from the Nihon University in Japan and completed Master’s in Ecology and Evolutionary Biology at The University of Arizona. He is also associated with Museum of Vertebrate Zoology at UC Berkeley.
So, let’s join Mr. Suzuki to our latest round of interviews on ‘Life as research scientist’:
Q. Let us start with your research topic. What is your research area? Will you please tell us a bit more on this? What did you find?
Taichi Suzuki: My research topic is focused on ‘Host associated microbial ecology’. I am interested in understanding how symbiotic microbial community affects host (e.g. animals) health and evolution. I found correlation between obese-associated gut microbial community composition and geography (i.e. latitude). (more…)
A new class of molecules called acyldepsipeptides — ADEPs — may provide a new way to attack bacteria that have developed resistance to antibiotics. Researchers at Brown and MIT have discovered a way to increase the potency of ADEPs by up to 1,200 times. Their findings appear in the Journal of the American Chemical Society.
PROVIDENCE, R.I. [Brown University] — As concerns about bacterial resistance to antibiotics grow, researchers are racing to find new kinds of drugs to replace ones that are no longer effective. One promising new class of molecules called acyldepsipeptides — ADEPs — kills bacteria in a way that no marketed antibacterial drug does — by altering the pathway through which cells rid themselves of harmful proteins. (more…)
The human face is as unique as a fingerprint, no one else looks exactly like you. But what is it that makes facial morphology so distinct? Certainly genetics play a major role as evident in the similarities between parents and their children, but what is it in our DNA that fine-tunes the genetics so that siblings – especially identical twins – resemble one another but look different from unrelated individuals? A new study by researchers at the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has now shown that gene enhancers – regulatory sequences of DNA that act to turn-on or amplify the expression of a specific gene – are major players in craniofacial development. (more…)
By manipulating the timing of disease-causing mutations in the brains of developing mice, Brown University researchers have found that early genetic deletions in the thalamus may play an important role in course and severity of the developmental disease tuberous sclerosis complex. Findings appear in the journal Neuron.
PROVIDENCE, R.I. [Brown University] — Doctors often diagnose tuberous sclerosis complex (TSC) based on the abnormal growths the genetic disease causes in organs around the body. Those overt anatomical structures, however, belie the microscopic and mysterious neurological differences behind the disease’s troublesome behavioral symptoms: autism, intellectual disabilities, and seizures. In a new study in mice, Brown University researchers highlight a role for a brain region called the thalamus and show that the timing of gene mutation during thalamus development makes a huge difference in the severity of the disease. (more…)