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Brain may play key role in blood sugar metabolism and diabetes development

By Guest PostNovember 13, 2013Healthblood sugar level, blood sugar metabolism, brain, cell, diabetes development, diabetes research lab, glucose effectiveness, glucose regulation, hyperglycemia, hypothesis, insulin dependent mechanisms, journal nature, key role, matthias tscho, michael w schwartz, pancreas, randy seeley, sensitivity to insulin, sugar level, two system model, type 2 diabetes, united states, vicious cycle

A growing body of evidence suggests that the brain plays a key role in glucose regulation and the development of type 2 diabetes, researchers write in the Nov. 7 ssue of the journal Nature. If the hypothesis is correct, it may open the door to entirely new ways to prevent and treat this disease, which is projected to affect one in three adults in the United States by 2050.

In the paper, lead author Dr. Michael W. Schwartz, UW professor of medicine and director of the Diabetes and Obesity Center of Excellence, and his colleagues from the universities of Cincinnati, Michigan, and Munich, note that the brain was originally thought to play an important role in maintaining normal glucose metabolism With the discovery of insulin in the 1920s, the focus of research and diabetes care shifted to almost exclusively to insulin. Today, almost all treatments for diabetes seek to either increase insulin levels or increase the body’s sensitivity to insulin. (more…)

Previous Studies on Toxic Effects of BPA Couldn’t be Reproduced, says MU Research Team

By Guest PostJanuary 9, 2013Environmentagouti, agouti signaling protein, animal numbers, asip, bpa, cheryl rosenfeld, controversial chemical, dietary supplement, equal ratios, estrogenic compound, exposure, famine, fat tissue, frederick vomsaal, gene, genistein, humans, metabolic disorders, mice, obesity, obesity related disease, offspring, pancreas, plants, plastic bottles, replicate, reproduce, soy beans, thrifty genotype, type 2 diabetes, university of missouri, uterine environments, womb, yellow coat color

The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible.

COLUMBIA, Mo. — Following a three-year study using more than 2,800 mice, a University of Missouri researcher was not able to replicate a series of previous studies by another research group investigating the controversial chemical BPA. The MU study is not claiming that BPA is safe, but that the previous series of studies are not reproducible. The MU study, published in the Proceedings of the National Academy of Sciences, also investigated an estrogenic compound found in plants, genistein, in the same three-year study.

“Our findings don’t say anything about the positive or negative effects of BPA or genistein,” said Cheryl Rosenfeld, associate professor of biomedical sciences in MU’s Bond Life Science Center. “Rather, our series of experiments did not detect the same findings as reported by another group on the potential developmental effects of BPA and genistein when exposure of young occurs in the womb.” (more…)

Preventing Pancreatic Cell Death in Type 1 Diabetes

By Guest PostNovember 9, 2011Health1 diabetes, beta cells, brehm foundation, diabetes researchers, excessive blood glucose levels, first biomarker, hormone insulin, juvenile diabetes research foundation, kevan c. herold, measuring dna expression, national academy of sciences, online early edition, pancreas, preventing pancreatic cell death, progression of the disease, symptoms of hyperglycemia, yale university

Diabetes researchers at Yale University have developed a method to detect and measure the destruction of beta cells that occurs in the pancreas by measuring DNA expression in the blood. The destruction of beta cells leads, over time, to type 1 diabetes. Their finding could ultimately lead to a treatment that stops the progression of the disease. The paper appears in the Online Early Edition of the Proceedings of the National Academy of Sciences.

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Tag Archives: pancreas

Brain may play key role in blood sugar metabolism and diabetes development

Previous Studies on Toxic Effects of BPA Couldn’t be Reproduced, says MU Research Team

Preventing Pancreatic Cell Death in Type 1 Diabetes