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Brain may play key role in blood sugar metabolism and diabetes development

A growing body of evidence suggests that the brain plays a key role in glucose regulation and the development of type 2 diabetes, researchers write in the Nov. 7 ssue of the journal Nature. If the hypothesis is correct, it may open the door to entirely new ways to prevent and treat this disease, which is projected to affect one in three adults in the United States by 2050.

In the paper, lead author Dr. Michael W. Schwartz, UW professor of medicine and director of the Diabetes and Obesity Center of Excellence, and his colleagues from the universities of Cincinnati, Michigan, and Munich, note that the brain was originally thought to play an important role in maintaining normal glucose metabolism With the discovery of insulin in the 1920s, the focus of research and diabetes care shifted to almost exclusively to insulin. Today, almost all treatments for diabetes seek to either increase insulin levels or increase the body’s sensitivity to insulin. (more…)

Vicious cycle: Changes in brain chemistry sustain obesity

By Guest PostJune 25, 2013Sciencealpha msh, amparo romero, bogdan litvinov, brain cells, brain chemistry, breakdown, brown university, calorie burning, cell, change, chemical called tudca, cycle, diet induced obesity, eduardo a nillni, endoplasmic reticulum, er, gene, high calorie diet, hormone, hormone trh, isin cakir, key enzyme, key proteins, leptin, lifespan researcher, mario perello, nicole cyr, normal weight, obesity, pc2, pomc, pro opiomelanocortin, production, protein processing mechanism, rhode island hospital, ronald stuart, vicious cycle

In a new discovery reported in the Journal of Biological Chemistry, Brown University and Lifespan researchers show that in the brain cells of rats, obesity impedes the production of a hormone that curbs appetite and inspires calorie burning. The root cause appears to be a breakdown in the protein-processing mechanism of the cells. In the lab, the researchers showed they could fix the breakdown with drugs.

PROVIDENCE, R.I. [Brown University] — With obesity reaching epidemic levels in some parts of the world, scientists have only begun to understand why it is such a persistent condition. A study in the Journal of Biological Chemistry adds substantially to the story by reporting the discovery of a molecular chain of events in the brains of obese rats that undermined their ability to suppress appetite and to increase calorie burning. (more…)

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Brain may play key role in blood sugar metabolism and diabetes development

Vicious cycle: Changes in brain chemistry sustain obesity