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Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

New Insights into How Genetic Differences among Individuals Influence Breast Cancer Risk from Low-Dose Radiation

By Guest PostOctober 17, 2012Health, Scienceandy wyrobek, antoine snijders, berkeley lab, breast cancer, cancer risk, cellular, cellular proliferation, chemical therapy, ct scan, department, dna repair, energy, gene, genetic makeup, gland cancer, immune response, ionizing radiation, joe gray, low dose, mammary tissue, mechanism, mice, non radiation, radiotherapy, resistance, risk, scientist, strain, survival outcome, therapy, tissue mechanism, tissue stress, woman

Berkeley Lab research could lead to new ways to ID women who have higher risk of breast cancer from low-dose radiation

Scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have identified tissue mechanisms that may influence a woman’s susceptibility or resistance to breast cancer after exposure to low-dose ionizing radiation, such as the levels used in full-body CT scans and radiotherapy.

The research could lead to new ways to identify women who have higher or lower risks of breast cancer from low-dose radiation. Such a predictive tool could help guide the treatment of cancer patients who may be better served by non-radiation therapies. (more…)

Scientists Dramatically Reduce Plaque-Forming Substances in Mice with Alzheimer’s Disease

By Guest PostSeptember 8, 2012Sciencea beta peptides, ajaya kunwar, alzheimer's disease, amp kinase, ampk, amyloid beta, amyloid precursor protein, app, chemical reaction, chhavy tep, cognitive decline, compound, cycle, dong ju park, endoplasmic reticulum, enzyme, er, fat, genetic manipulation, glucose, jae cheon ryu, jnk3, metabolism, mice, mouse brain, mtor pathway, ohio state university, proteins, reduction, rna expression, sung ok yoon, symptom, tae hee lim, type 2 diabetes, yong jae shin

COLUMBUS, Ohio – Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer’s disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer’s disease.

That is the most dramatic reduction in this compound reported to date in published research.

The compounds are amyloid beta, or A-beta peptides; peptides are proteins, but are shorter in length. When A-beta peptides accumulate in excessive amounts in the brain, they can form plaques, which are a hallmark of Alzheimer’s disease. (more…)

Precautions for Tick-Borne Disease Extend “Beyond Lyme”

By Guest PostSeptember 7, 2012Health, Naturealcohol, bacterial infection, blacklegged tick, disease, eeid, ehrlichia, ehrlichiosis, ellen stromdahl, fever, graham hickling, hicklings research, human bite, human biting, human disease, jean tsao, lyme disease, mice, michigan, mid atlantic, mid virginia, nymphal, pathogen, rickettsiosis, sam scheiner, star ticks, state, state university, tennessee, tick, tick bite, tick borne, united states, university, white footed, wildlife

Save the tick that bites you: it may not be the one you think

This year’s mild winter and early spring were a bonanza for tick populations in the eastern United States. Reports of tick-borne disease rose fast.

While Lyme disease is the most common tick-borne disease in the Northeast and Upper Midwest, new research results emphasize that it is not the greatest cause for concern in most Southeastern states.

The findings are published today in a paper in the journal Zoonoses and Public Health. (more…)

Photoreceptor Transplant Restores Vision in Mice

By Guest PostApril 19, 2012Scienceblindness, brain, central nervous system, cones, degenerate retina, degenerative eye diseases, degenerative eye disorders, diabetes, embryonic stem cells, institute of ophthalmology, macular degeneration, mice, photoreceptor transplantation, photoreceptors, rachael pearson, retinitis pigmentosa, rob buckle, robin ali, rods, stem cell therapies, transplanting photoreceptors, ucl, vision, visual information, visually impaired

Scientists from the UCL Institute of Ophthalmology have shown for the first time that transplanting light-sensitive photoreceptors into the eyes of visually impaired mice can restore their vision.

The research, published in Nature, suggests that transplanting photoreceptors – light-sensitive nerve cells that line the back of the eye – could form the basis of a new treatment to restore sight in people with degenerative eye diseases. (more…)

Loss of Appetite Deciphered in Brain Cell Circuit

By Guest PostMarch 14, 2012Scienceanorexia nervosa, body, brain, brain development, cancer chemotherapy, excitatory signal, experimental result, food aversions, function, gaba, glutamate, hypothalamus, loss of appetite, meal, mice, michael s clark, michael schwartz, nausea, nerve cells, nucleus tractus solitarus, parabrachial nucleus, point of emaciation, qi wu, ralph brinster, receptor, richard d palmiter, starvation, substance, transgenic mice, university of pennsylvania, university of washington

The meal is pushed way, untouched. Loss of appetite can be a fleeting queasiness or continue to the point of emaciation. While it’s felt in the gut, more is going on inside the head.

New findings are emerging about brain and body messaging pathways that lead to loss of appetite, and the systems in place to avoid starvation. (more…)

New Mouse Reference Library Should Speed Gene Discoveries

By Guest PostFebruary 17, 2012Sciencecc, collaborative cross, david threadgill, francis s collins, genes, genetic information, genetic sequences, genetic variation, human disease, jackson laboratory, lab mice, manual, mice, north carolina state university, oxford university, tel aviv university

Genetic information provided by a large group of specially designed mice could pave the way to faster human health discoveries and transform the ways people battle and prevent disease.

In 15 papers published Feb. 16 in the Genetics Society of America journals Genetics and G3:Genes/Genomes/Genetics, researchers from North Carolina State University, the University of North Carolina at Chapel Hill, The Jackson Laboratory and other universities and labs across the globe highlight a new genetic resource that could aid development of more effective treatments for any number of human diseases. (more…)

Why Bad Immunity Genes Survive

By Guest PostFebruary 10, 2012Health, Scienceankylosing spondylitis, antagonistic co evolution, antibiotics, arms race, autoimmune diseases, bacteria, cells, cornelius whitney hyzer, gene, genetics, george gilchrist, germs, immune system, infection, infectious diseases, james ruff, jason kubinak, major histocompatibility complex, mhc, mhc variants, mhcs, mice, national science foundation, parasite, pathogens, patricia slev, people, protein, university of utah, variant, vertebrate animals, virus, wayne potts

*Study implicates “arms race” between genes and germs*

Biologists have found new evidence of why mice, people and other vertebrate animals carry thousands of varieties of genes to make immune-system proteins named MHCs–even though some of those genes make vertebrate animals susceptible to infections and to autoimmune diseases.

“Major histocompatibility complex” (MHC) proteins are found on the surfaces of most cells in vertebrate animals. They distinguish proteins like themselves from foreign proteins, and trigger an immune response against these foreign invaders. (more…)

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