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UW work contributes to largest international study of Alzheimer’s genes

Eleven regions of the human genome have been newly discovered to influence the onset of Alzheimer’s disease. The findings stem from the largest international study ever conducted on this disorder, which causes gradual memory loss and other forms of cognitive decline in older people.

As of 2009, 10 genes were known to be related to Alzheimer’s, the result of about a quarter-century of research. Yet the reasons behind individual susceptibility or resistance to the disease continued to be poorly understood. In February of 2011, four international research groups studying Alzheimer’s disease genetics united to more quickly identify other genes related to the disorder. (more…)

Scientists Dramatically Reduce Plaque-Forming Substances in Mice with Alzheimer’s Disease

By Guest PostSeptember 8, 2012Sciencea beta peptides, ajaya kunwar, alzheimer's disease, amp kinase, ampk, amyloid beta, amyloid precursor protein, app, chemical reaction, chhavy tep, cognitive decline, compound, cycle, dong ju park, endoplasmic reticulum, enzyme, er, fat, genetic manipulation, glucose, jae cheon ryu, jnk3, metabolism, mice, mouse brain, mtor pathway, ohio state university, proteins, reduction, rna expression, sung ok yoon, symptom, tae hee lim, type 2 diabetes, yong jae shin

COLUMBUS, Ohio – Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer’s disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer’s disease.

That is the most dramatic reduction in this compound reported to date in published research.

The compounds are amyloid beta, or A-beta peptides; peptides are proteins, but are shorter in length. When A-beta peptides accumulate in excessive amounts in the brain, they can form plaques, which are a hallmark of Alzheimer’s disease. (more…)

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UW work contributes to largest international study of Alzheimer’s genes

Scientists Dramatically Reduce Plaque-Forming Substances in Mice with Alzheimer’s Disease