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The Compound in the Mediterranean Diet that Makes Cancer Cells ‘Mortal’

By Guest PostJune 1, 2013Healthalper yilmaz, andrea doseff, apigenin, benefits of nutrients, cancer cell behavior, cancer cells, caps, chemotherapeutic drugs, compound, daniel arango, erich grotewold, flavonoids, hnrnpa2, kengo morohashi, mediterranean diet, mortal, mrna, nutraceuticals, ohio state university, plant-based foods, proteins, rna, single molecule, superpower, technique to fishing

Scientists Design ‘Fishing’ Technique to Show How Foods Improve Health

COLUMBUS, Ohio – New research suggests that a compound abundant in the Mediterranean diet takes away cancer cells’ “superpower” to escape death.

By altering a very specific step in gene regulation, this compound essentially re-educates cancer cells into normal cells that die as scheduled.

One way that cancer cells thrive is by inhibiting a process that would cause them to die on a regular cycle that is subject to strict programming. This study in cells, led by researchers at The Ohio State University’s Comprehensive Cancer Center, found that a compound in certain plant-based foods, called apigenin, could stop breast cancer cells from inhibiting their own death. (more…)

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

Compound in Grapes, Red Wine Could be Key to Fighting Prostate Cancer

By Guest PostNovember 10, 2012Healthaggressive tumor, animal model, cancer, cardiovascular health, cell, chemotherapy, clinical trials, compound, granzyme b, grape skins, grocery stores, human health, michael nicholl, missouri, perforin, prostate cancer, prostate tumor, proteins, radiation therapy, radiation treatment, red wine, resveratrol, stroke prevention, therapeutic agent, university

MU researcher finds that prostate tumor cells are more susceptible to treatment after being exposed to resveratrol, a compound found in grape skins and red wine.

Resveratrol, a compound found commonly in grape skins and red wine, has been shown to have several beneficial effects on human health, including cardiovascular health and stroke prevention. Now, a University of Missouri researcher has discovered that the compound can make prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors.

“Other studies have noted that resveratrol made tumor cells more susceptible to chemotherapy, and we wanted to see if it had the same effect for radiation therapy,” said Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine. “We found that when exposed to the compound, the tumor cells were more susceptible to radiation treatment, but that the effect was greater than just treating with both compounds separately.” (more…)

Nearby Super-Earth Likely a Diamond Planet

By Guest PostOctober 11, 2012Science55 cancri e, atmosphere, cancer, carbon, carbon rich, chemistry, compound, constellation, core, david spergel, Diamond, diamond planet, earth, earth mass, element, fahrenheit, formation, gas planet, graphite, habitable world, hyper speed, interior, kanani lee, mass, mineral, molten iron, mountain formation, nikku madhusudhan, olivier mousis, oxygen, planet, plate tectonics, princeton university, radius, rocky planet, scientist, seismic activity, silicates, silicon carbide, size, specific characteristics, star, stellar composition, super earth, surface, temperature, thermal evolution, volcanism, water, yale university

New research led by Yale University scientists suggests that a rocky planet twice Earth’s size orbiting a nearby star is a diamond planet.

“This is our first glimpse of a rocky world with a fundamentally different chemistry from Earth,” said lead researcher Nikku Madhusudhan, a Yale postdoctoral researcher in physics and astronomy. “The surface of this planet is likely covered in graphite and diamond rather than water and granite.”

The paper reporting the findings has been accepted for publication in the journal Astrophysical Journal Letters. (more…)

Scientists Dramatically Reduce Plaque-Forming Substances in Mice with Alzheimer’s Disease

By Guest PostSeptember 8, 2012Sciencea beta peptides, ajaya kunwar, alzheimer's disease, amp kinase, ampk, amyloid beta, amyloid precursor protein, app, chemical reaction, chhavy tep, cognitive decline, compound, cycle, dong ju park, endoplasmic reticulum, enzyme, er, fat, genetic manipulation, glucose, jae cheon ryu, jnk3, metabolism, mice, mouse brain, mtor pathway, ohio state university, proteins, reduction, rna expression, sung ok yoon, symptom, tae hee lim, type 2 diabetes, yong jae shin

COLUMBUS, Ohio – Scientists have found that eliminating an enzyme from mice with symptoms of Alzheimer’s disease leads to a 90 percent reduction in the compounds responsible for formation of the plaques linked to Alzheimer’s disease.

That is the most dramatic reduction in this compound reported to date in published research.

The compounds are amyloid beta, or A-beta peptides; peptides are proteins, but are shorter in length. When A-beta peptides accumulate in excessive amounts in the brain, they can form plaques, which are a hallmark of Alzheimer’s disease. (more…)

Compound from Wild Tomatoes is Natural, Effective Herbicide

By Guest PostApril 29, 2012Environmentchemical, compound, concentration, deet, entomologist, george kennedy, groundwater contamination, herbicidal effect, herbicide, human, insect repellent, insecticide, mike roe, nontoxic herbicide, organic farming, plant, soil, undecanone, weed, wild tomato

A naturally occurring compound derived from wild tomato plants is also a fast-acting, nontoxic herbicide, according to researchers at North Carolina State University.

NC State entomologist Dr. Mike Roe had previously worked with the compound – known as 2-undecanone – as a natural replacement for the chemical DEET in insect repellents. Both he and his NC State colleague, entomologist Dr. George Kennedy, were exploring whether 2-undecanone could be used as an insecticide on plants, when they noticed an unexpected side effect: it killed the plants. (more…)

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