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Potassium in brain could be key to fighting Huntington’s disease

By Guest PostApril 26, 2014Healthastrocytes, brain tissue, culture wars, guido buenstorf, huntingtons disease, mark smith, meinung in millisekunden, neurons, rebound effekt, role, secular faith, sparsame technik, stephan bruns, ucla researchers

Researchers were able to improve walking and prolong survival in a mouse model by tweaking potassium levels

By boosting the ability of a specific type of cell to absorb potassium in the brain, UCLA researchers were able to improve walking and prolong survival in a mouse model of Huntington’s disease.

Their findings, published March 30 in the online edition of the journal Nature Neuroscience, could point to new drug targets for treating the devastating disease, which strikes one in every 20,000 Americans. (more…)

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

Huntington’s Disease

By Guest PostApril 8, 2012Healthalzheimer's disease, amyloid fiber, amyloid seeding assay, asa, brain tissue, david w colby, fluorescent detector, hd, huntingtin, huntingtons disease, monomeric polyglutamine peptide, neurological disease, novel technology, prion disease, protein, sharad gupta, shyann jie, thioflavin t, university of delaware

UD researchers develop novel technique for early detection of misfolded protein

University of Delaware assistant professor David W. Colby is co-author of a paper in the March 23 issue of the Journal of Biological Chemistry that suggests protein misfolding may occur early in the pathogenesis, or development, of Huntington’s disease.

Huntington’s disease (HD) is one of several neurological diseases, such as Alzheimer’s disease or prion disease, associated with proteins that fold into abnormal structures. HD is characterized by progressive motor impairment, cognitive decline and behavioral abnormalities, and ultimately death. (more…)

Novel Nanoparticle Mimicking Virus Offers New Route to Gene Therapy

By Guest PostDecember 10, 2011Sciencebrain tumors, cancer, caroline e weller, christopher j cheng, cystic fibrosis, diseases, gene therapy, healthy cells, huntingtons disease, hydrophobic, immune reactions, materials, mouse tumor model, nanoparticle, non viral gene therapy, novel chemistry, polymers, positive electric charge, repair, symptoms, treatments, viral gene therapy, w mark saltzman, water molecules, water repellant, yale university, zhaozhong jiang

Researchers at Yale University have developed a novel nanoparticle with promising applications in gene therapy, a type of medical treatment that addresses the root causes of diseases now typically treated for symptoms.

The advance could lead to new therapies for many forms of cancer, including brain tumors, as well as for cystic fibrosis and Huntington’s Disease. (more…)

Tag Archives: huntingtons disease

Potassium in brain could be key to fighting Huntington’s disease

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

Huntington’s Disease

Novel Nanoparticle Mimicking Virus Offers New Route to Gene Therapy