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Copper on the Brain at Rest: Berkeley Lab Reports Proper Copper Levels Essential to Spontaneous Neural Activity

By Guest PostMarch 14, 2015Science3d printed homes, alzheimer, apis cor, berkeley lab, chris chang, erdaehnlicher atmosphaere, m zwerge, mark griswold, parkinson, planeten, quantum annealer, quantum inspired algorithms, reactive oxygen species, rest, willis towers watson, zebra fish

In recent years it has been established that copper plays an essential role in the health of the human brain. Improper copper oxidation has been linked to several neurological disorders including Alzheimer’s, Parkinson’s, Menkes’ and Wilson’s. Copper has also been identified as a critical ingredient in the enzymes that activate the brain’s neurotransmitters in response to stimuli. Now a new study by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has shown that proper copper levels are also essential to the health of the brain at rest. (more…)

Study of the machinery of cells reveals clues to neurological disorder

By Guest PostMay 16, 2013Sciencebiogenesis, cell, charcot, common neurological disorder, crop plants, cross talk, disease causing mutations, embo reports, energy factories, eth zurich, fatty acids, fragmentation of mitochondria, function, humans, kate mcintosh, marie, metabolism, michael schrader, mitochondria, organelles, organelles peroxisomes, peroxisomal division, peroxisomes, reactive oxygen species, researcher, sofia guimaraes, symptoms, tooth disease, touch sensation, uk, university of exeter, yeast

Investigation by researchers from the University of Exeter and ETH Zurich has shed new light on a protein which is linked to a common neurological disorder called Charcot-Marie-Tooth disease.

The team has discovered that a protein previously identified on mitochondria – the energy factories of the cell – is also found on the fat-metabolising organelles peroxisomes, suggesting a closer link between the two organelles.

Charcot-Marie-Tooth disease is currently incurable and affects around one in every 2,500 people in the UK, meaning that it is one of the most common inherited neurological disorders, thus understanding the molecular basis of the disease is of great importance. Symptoms can range from tremors and loss of touch sensation in the feet and legs to difficulties with breathing, swallowing, speaking, hearing and vision. (more…)

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

By Guest PostNovember 11, 2012Healthalzheimers, antidepressants, bacterial membrane, berkeley lab, cells, cerebral cortex, chemist, coenzyme q, cognitive decline, compound, cynthia mcmurray, DNA, genetic disorder, genetic mutation, huntingtons disease, loss, mice, mitochondria, mitochondrial function, molecules, motor coordination, motor skills, muscle coordination, neurodegenerative diseases, neuron, organelle, oxidative damage, parkinson's, peter wipf, pittsburgh, power plant, reactive oxygen species, striatum, suppress, survival, symptoms, synthetic antioxidant, university, untreated neuronal cultures, vitamin e, xjb 5 131, xjb treated mice, zhiyin xun

Initial results in mice could lead to new way to fight neurodegenerative diseases

There’s new hope in the fight against Huntington’s disease. A group of researchers that includes scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) have designed a compound that suppresses symptoms of the devastating disease in mice.

The compound is a synthetic antioxidant that targets mitochondria, an organelle within cells that serves as a cell’s power plant. Oxidative damage to mitochondria is implicated in many neurodegenerative diseases including Alzheimer’s, Parkinson’s, and Huntington’s. (more…)

Solving The Mystery of An Old Drug That May Reduce Cancer Risk

By Guest PostJanuary 19, 2012Health, Scienceanti diabetic drug, anti diabetic function, antioxidant, breast, cancer, cancer risk, carcinogenesis, cellular mutation rate, colon, diabetics, dna damage, gerardo ferbeyre, mcgill university, metformin, michael pollak, mitochondria, nutrient, rates of cancer, reactive oxygen species, reduction in risk, ros, scotland, type ii diabetes, université de montréal, university of montreal

In 2005, news first broke that researchers in Scotland found unexpectedly low rates of cancer among diabetics taking metformin, a drug commonly prescribed to patients with Type II diabetes. Many follow-up studies reported similar findings, some suggesting as much as a 50-per-cent reduction in risk. How could this anti-diabetic drug reduce the risk of developing cancer and what were the mechanisms involved?

In a paper published today in the journal Cancer Prevention Research, researchers from McGill University and the University of Montreal reported an unexpected finding: they learned that exposure to metformin reduces the cellular mutation rate and the accumulation of DNA damage. It is well known that such mutations are directly involved in carcinogenesis, but lowering cancer risk by inhibiting the mutation rate has never been shown to be feasible. (more…)

Tag Archives: reactive oxygen species

Copper on the Brain at Rest: Berkeley Lab Reports Proper Copper Levels Essential to Spontaneous Neural Activity

Study of the machinery of cells reveals clues to neurological disorder

Berkeley Lab Scientists Help Develop Promising Therapy for Huntington’s Disease

Solving The Mystery of An Old Drug That May Reduce Cancer Risk