A team of researchers from have discovered that lycopene – the red pigment in tomatoes – is extremely successful at guarding against the harmful effects of radiation.
Dr Ruth Edge from The University of Manchester, together with her colleagues Professor George Truscott from Keele University and Professors Fritz Boehm & Christian Witt from Berlin, undertook a study of lycopene (one of the carotenoids – plant pigments found in many fruits and vegetables) and its effectiveness at protecting against radiation at the University of Manchester’s Dalton Cumbrian Facility, part of the Dalton Nuclear Institute.
MU researcher finds that prostate tumor cells are more susceptible to treatment after being exposed to resveratrol, a compound found in grape skins and red wine.
Resveratrol, a compound found commonly in grape skins and red wine, has been shown to have several beneficial effects on human health, including cardiovascular health and stroke prevention. Now, a University of Missouri researcher has discovered that the compound can make prostate tumor cells more susceptible to radiation treatment, increasing the chances of a full recovery from all types of prostate cancer, including aggressive tumors.
“Other studies have noted that resveratrol made tumor cells more susceptible to chemotherapy, and we wanted to see if it had the same effect for radiation therapy,” said Michael Nicholl, an assistant professor of surgical oncology in the MU School of Medicine. “We found that when exposed to the compound, the tumor cells were more susceptible to radiation treatment, but that the effect was greater than just treating with both compounds separately.” (more…)
TORONTO, ON — Low oxygen levels in tumors can be used to predict cancer recurrence in men with intermediate-risk prostate cancer even before they receive radiation therapy.(more…)
Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.
Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells.(more…)
A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to reduce the risks for patients who are most susceptible to long-term damage.
Hodgkin’s lymphoma is one of the most treatable cancers, with more than 90 percent of patients surviving after a combination of radiation and chemotherapy. But nearly 20 percent of patients treated as children develop a second cancer within 30 years. The younger the patients are when treated and the higher the radiation dose, the greater the risk. This late side effect of treatment is the second leading cause of death for long-term Hodgkin’s survivors. (more…)
