Tag Archives: differentiation

Lunar impacts created seas of molten rock

A new analysis of data from NASA’s Lunar Orbiter Laser Altimeter (LOLA) shows that molten rock may have been present on the Moon more recently and for longer periods than previously thought. Differentiation — a settling out of rock layers as liquid rock cools — would require thousands of years and a fluid rock sea at least six miles deep.

PROVIDENCE, R.I. [Brown University] — Early in the Moon’s history an ocean of molten rock covered its entire surface. As that lunar magma ocean cooled over millions of years, it differentiated to form the Moon’s crust and mantle. But according to a new analysis by planetary scientists from Brown University, this wasn’t the last time the Moon’s surface was melted on a massive scale. (more…)

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Beacons Light up Stem Cell Transformation

In a new study, Brown University researchers demonstrate a new tool for visually tracking in real-time the transformation of a living population of stem cells into cells of a specific tissue. The “molecular beacons,” which could advance tissue engineering research, light up when certain genes are expressed and don’t interfere with the development or operation of the stem cells.

PROVIDENCE, R.I. [Brown University] — A novel set of custom-designed “molecular beacons” allows scientists to monitor gene expression in living populations of stem cells as they turn into a specific tissue in real-time. The technology, which Brown University researchers describe in a new study, provides tissue engineers with a potentially powerful tool to discover what it may take to make stem cells transform into desired tissue cells more often and more quickly. That’s a key goal in improving regenerative medicine treatments. (more…)

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Two Genetic Variations Predict Second Cancers after Radiation Treatment for Children with Hodgkin’s

A genome-wide association study published in the August issue of Nature Medicine has found two tiny genetic variations that can predict which patients with Hodgkin’s lymphoma are most likely to develop radiation-induced second cancers years after treatment. Knowing in advance who is at risk could help physicians tailor treatment to reduce the risks for patients who are most susceptible to long-term damage.

Hodgkin’s lymphoma is one of the most treatable cancers, with more than 90 percent of patients surviving after a combination of radiation and chemotherapy. But nearly 20 percent of patients treated as children develop a second cancer within 30 years. The younger the patients are when treated and the higher the radiation dose, the greater the risk. This late side effect of treatment is the second leading cause of death for long-term Hodgkin’s survivors. (more…)

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