Fats spur cells to divide faster, promoting tumor growth
New UCLA research could help explain the link between a high-cholesterol diet and an elevated risk for colon cancer. (more…)
UCLA scientists get closer to creating blood stem cells in the lab
Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have made several discoveries that are critically important to understanding how blood stem cells are created and maintained — both in the body and in the laboratory. (more…)
Brain cancer researcher travels to Oslo for dissertation defense
As winter weather hit Newark, Del., on Sunday, Dec. 8, a University of Delaware brain cancer researcher escaped the storm by traveling to Oslo, Norway, of all places.
The Norwegian capital also received its first snow of the season that day, but it only accumulated to about three inches, according to Deni Galileo, associate professor of biological sciences at UD. He traveled to Oslo to take part in the Ph.D. defense of Mrinal Joel, a University of Oslo doctoral student who, like Galileo, is working on the most lethal type of brain cancer, Glioblastoma multiforme. (more…)
UCLA stem cell researchers have found that a gene therapy regimen can safely restore immune systems to children with so-called “bubble boy” disease, a life-threatening condition that if left untreated can be fatal within one to two years.
In the 11-year study, researchers were able to test two therapy regimens for 10 children with ADA-deficient severe combined immunodeficiency (SCID), which has come to be known as “bubble boy” disease because some of its victims have been forced to live in sterile environments. (more…)
UCLA researchers have discovered a type of cell that is the “missing link” between bone marrow stem cells and all the cells of the human immune system, a finding that will lead to a greater understanding of how a healthy immune system is produced and how disease can lead to poor immune function.
The research was done using human bone marrow, which contains all the stem cells that produce blood during post-natal life. (more…)
Scientists have for the first time watched and manipulated stem cells as they regenerate tissue in an uninjured mammal, Yale researchers report July 1 online in the journal Nature.
Using a sophisticated imaging technique, the researchers also demonstrated that mice lacking a certain type of cell do not regrow hair. The same technique could shed light on how stem cells interact with other cells and trigger repairs in a variety of other organs, including lung and heart tissue.
“This tells us a lot about how the tissue regeneration process works,” said Valentina Greco, assistant professor of genetics and of dermatology at the Yale Stem Cell Center, researcher for the Yale Cancer Center and senior author of the study. (more…)
UCLA stem cell researchers have shown that insulin and nutrition prevent blood stem cells from differentiating into mature blood cells in Drosophila, the common fruit fly, a finding that has implications for studying inflammatory response and blood development in response to dietary changes in humans.
Keeping blood stem cells, or progenitor cells, from differentiating into blood cells is important as blood stem cells are needed to create the blood supply for the adult fruit fly. (more…)
Breast cancer stem cells, thought to be the sole source of tumor recurrence, are known to be resistant to radiation therapy and don’t respond well to chemotherapy.
Now, researchers with the UCLA Department of Radiation Oncology at UCLA’s Jonsson Comprehensive Cancer Center report for the first time that radiation treatment, despite killing half of all tumor cells during every treatment, transforms other cancer cells into treatment-resistant breast cancer stem cells. (more…)
