Berkeley Lab scientists lead broadest survey yet of RNA activity in any animal
A consortium led by scientists from the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) has conducted the largest survey yet of how information encoded in an animal genome is processed in different organs, stages of development, and environmental conditions. Their findings paint a new picture of how genes function in the nervous system and in response to environmental stress. (more…)
The internal circadian clock of a Drosophila (fruit fly) can be synchronised using vibrations, according to research published today in the journal Science. The study suggests that an animal’s own movements can influence its clock.
The circadian clock, which underlies the daily rhythms characterising most of our bodily functions, including the sleep cycle, is mainly set by diurnal changes in light and temperature. (more…)
Baltimore, MD— One classical question in developmental biology is how different tissue types arise in the correct position of the developing embryo. While one signaling pathway that controls this process has been well described, unexpected findings from a team led by Carnegie’s Steven Farber reveal the importance of polyunsaturated fatty acid metabolism in this process. It is published online December 12 in Developmental Cell.
Fatty acids serve as sources of energy, the building materials of cellular membranes, and as signals for sending messages between cells. Enzymes are needed to activate free fatty acids so that they are useful for cellular processes. The enzymes that perform this function are called acyl-CoA synthetases, often shortened to ACS. (more…)
Biologists have been observing the “selfish” genetic entity segregation distorter (SD) in fruit flies for decades. Its story is a thriller among molecules, in which the SD gene destroys maturing sperm that have a rival chromosome. A new study reveals a tactic that gives SD’s villainy an extra edge.
PROVIDENCE, R.I. [Brown University] — For a bunch of inanimate chemical compounds, the nucleic and amino acids caught up in the infamous “selfish” segregation distorter (SD) saga have put on quite a soap opera for biologists since the phenomenon was discovered in fruit flies 50 years ago. A new study, a highlight in the March issue of the journal Genetics, provides the latest plot twist. (more…)
COLUMBUS, Ohio – Scientists have delved deeper into the evolutionary history of the fruit fly than ever before to reveal the genetic activity that led to the development of wings – a key to the insect’s ability to survive.
The wings themselves are common research models for this and other species’ appendages. But until now, scientists did not know how the fruit fly, Drosophila melanogaster, first sprouted tiny buds that became flat wings. (more…)
Berkeley Scientists Find that a Critical Transcription Factor Co-exists in Two Distinct States
The enormously diverse complexity seen amongst individual species within the animal kingdom evolved from a surprisingly small gene pool. For example, mice effectively serve as medical research models because humans and mice share 80-percent of the same protein-coding genes. The key to morphological and behavioral complexity, a growing body of scientific evidence suggests, is the regulation of gene expression by a family of DNA-binding proteins called “transcription factors.” Now, a team of researchers with the U.S. Department of Energy’s Lawrence Berkeley National Laboratory (Berkeley Lab) and the University of California (UC) Berkeley has discovered the secret behind how one these critical transcription factors is able to perform – a split personality. (more…)
Researchers at Michigan State University have discovered a protein that does its best work with one foot in the grave.
The study, which appears in the current issue of the Journal of Biological Chemistry, focuses on the nontraditional lifestyle of Retinoblastoma tumor suppressor proteins, which could lead to new ways to treat cancer.
“Retinoblastoma proteins are unique in that they use controlled destruction to do their jobs in a timely but restrained fashion,” said Liang Zhang, a lead author and MSU cell and molecular biology graduate student. “This is an unusual way for proteins to act.” (more…)
Study part of growing body of knowledge surrounding gene-environment interplay
TORONTO, ON – It is time to put the nature versus nurture debate to rest and embrace growing evidence that it is the interaction between biology and environment in early life that influences human development, according to a series of studies recently published in a special edition of the Proceedings of the National Academy of Sciences (PNAS).
“Biologists used to think that our differences are pre-programmed in our genes, while psychologists argued that babies are born with a blank slate and their experience writes on it to shape them into the adults they become. Instead, the important question to be asking is, ‘How is our experience in early life getting embedded in our biology?’” says University of Toronto behavioural geneticist Marla Sokolowski. She is co-editor of the PNAS special edition titled “Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergarteners” along with professors Tom Boyce (University of British Columbia) and Gene Robinson (University of Illinois). (more…)
