Imagine that an invisible, microscopic invader has found its way into your body and hijacked the cellular machinery that keeps you healthy. Inhabiting the gray area between living and nonliving, the invader can only reproduce once it makes its new home inside of your cells, eventually causing you to fall ill. How do physicians and scientists combat this uninvited guest? (more…)
Using bacteria as bait, UA scientists caught wild ocean viruses and found that the genetic lines between virus types in nature are less blurred than previously thought.
A fishing expedition of microscopic proportions led by University of Arizona ecologists revealed that the lines between virus types in nature are less blurred than previously thought. (more…)
Berkeley Lab Researchers Discover New Rules for Single-Particle Imaging with Light-Emitting Nanocrystals
The term a “brighter future” might be a cliché, but in the case of ultra-small probes for lighting up individual proteins, it is now most appropriate. Researchers at the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered surprising new rules for creating ultra-bright light-emitting crystals that are less than 10 nanometers in diameter. These ultra-tiny but ultra-bright nanoprobes should be a big asset for biological imaging, especially deep-tissue optical imaging of neurons in the brain.
Working at the Molecular Foundry, a DOE national nanoscience center hosted at Berkeley Lab, a multidisciplinary team of researchers led by James Schuck and Bruce Cohen, both with Berkeley Lab’s Materials Sciences Division, used advanced single-particle characterization and theoretical modeling to study what are known as “upconverting nanoparticles” or UCNPs. Upconversion is the process by which a molecule absorbs two or more photons at a lower energy and emits them at higher energies. The research team determined that the rules governing the design of UCNP probes for ensembles of molecules do not apply to UCNP probes designed for single-molecules. (more…)
New research into the origins of — and structural differences between — wrinkles, creases, and folds could have applications in many fields, from flexible electronic devices to dermatology to flexible sheets that become sticky when stretched. Findings from a Brown University research group appear in Proceedings of the Royal Society A.
PROVIDENCE, R.I. [Brown University] — Engineers from Brown University have mapped out the amounts of compression required to cause wrinkles, creases, and folds to form in rubbery materials. The findings could help engineers control the formation of these structures, which can be useful in designing nanostructured materials for flexible electronic devices or surfaces that require variable adhesion. (more…)
Better diagnosis and treatment of cancer could hinge on the ability to better understand a single cell at its molecular level. New research offers a more comprehensive way of analyzing one cell’s unique behavior, using an array of colors to show patterns that could indicate why a cell will or won’t become cancerous.
A University of Washington team has developed a new method for color-coding cells that allows them to illuminate 100 biomarkers, a ten-time increase from the current research standard, to help analyze individual cells from cultures or tissue biopsies. The work is published this week (March 19) in Nature Communications. (more…)
The adulthood of a midge fly is decidedly brief — about three days. But a new study of its mating swarm may yield lasting benefits for analyses of bird flocks, fish schools, human crowds and other forms of collective animal motion.
“This is a field where there’s been almost no quantitative data,” said Nicholas T. Ouellette of the Yale School of Engineering & Applied Science, principal investigator of the research, published Jan. 15 in the journal Scientific Reports. “What we’ve been able to do is put this in the laboratory, and that lets us take as much data as we want.” (more…)
NASA funds astrobiology research by Delaware Biotechnology Institute scientist
Does life exist anywhere else in the universe? That’s the type of broad but poignant question NASA likes to ask, according to Chandran Sabanayagam, associate scientist in the Bioimaging Center at the Delaware Biotechnology Institute (DBI). And he would know, because he’s preparing to help answer it.
NASA will receive $100 billion from the federal government over the next five years to assure America is number one in space exploration, according to Astrobiology.com. As part of its push to seek new partnerships and broaden its vision, NASA is offering grants to people conducting transformational science. With this opportunity, Sabanayagam is merging his love of physics and biology. (more…)
Study part of growing body of knowledge surrounding gene-environment interplay
TORONTO, ON – It is time to put the nature versus nurture debate to rest and embrace growing evidence that it is the interaction between biology and environment in early life that influences human development, according to a series of studies recently published in a special edition of the Proceedings of the National Academy of Sciences (PNAS).
“Biologists used to think that our differences are pre-programmed in our genes, while psychologists argued that babies are born with a blank slate and their experience writes on it to shape them into the adults they become. Instead, the important question to be asking is, ‘How is our experience in early life getting embedded in our biology?’” says University of Toronto behavioural geneticist Marla Sokolowski. She is co-editor of the PNAS special edition titled “Biological Embedding of Early Social Adversity: From Fruit Flies to Kindergarteners” along with professors Tom Boyce (University of British Columbia) and Gene Robinson (University of Illinois). (more…)
