Tag Archives: molecular foundry

Bright Future for Protein Nanoprobes

By Guest PostMay 2, 2014Sciencealexis ostrowski, berkeley lab, biology, brighter future, bruce cohen, building blocks, daniel gargas, doe, elektronische fussfessel, emory chan, erbium, fluorescent, free asymmetric, future, gewaltdelikte, heterocontact, james schuck, joerg kinzig, laboratory, mexican men, mexico murder rate, molecular foundry, nanocrystals, photobleach, polly myer, single molecules, sodium yttrium fluoride, ytterbium

Berkeley Lab Researchers Discover New Rules for Single-Particle Imaging with Light-Emitting Nanocrystals

The term a “brighter future” might be a cliché, but in the case of ultra-small probes for lighting up individual proteins, it is now most appropriate. Researchers at the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered surprising new rules for creating ultra-bright light-emitting crystals that are less than 10 nanometers in diameter. These ultra-tiny but ultra-bright nanoprobes should be a big asset for biological imaging, especially deep-tissue optical imaging of neurons in the brain.

Working at the Molecular Foundry, a DOE national nanoscience center hosted at Berkeley Lab, a multidisciplinary team of researchers led by James Schuck and Bruce Cohen, both with Berkeley Lab’s Materials Sciences Division, used advanced single-particle characterization and theoretical modeling to study what are known as “upconverting nanoparticles” or UCNPs. Upconversion is the process by which a molecule absorbs two or more photons at a lower energy and emits them at higher energies. The research team determined that the rules governing the design of UCNP probes for ensembles of molecules do not apply to UCNP probes designed for single-molecules. (more…)

Cooling Microprocessors with Carbon Nanotubes

By Guest PostFebruary 2, 2014Scienceaminopropyl trialkoxy silane, aps, berkeley lab, brett helms, carbon nanotubes, frank ogletree, heat transport efficiency, microprocessors, molecular foundry, nachiket raravikar, nanostructured systems, noble metals, ravi prasher, sumanjeet kaur, technology problems, thermal conductivity

Technique From Berkeley Lab’s Molecular Foundry Could Also Work with Graphene

“Cool it!” That’s a prime directive for microprocessor chips and a promising new solution to meeting this imperative is in the offing. Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have developed a “process friendly” technique that would enable the cooling of microprocessor chips through carbon nanotubes.

Frank Ogletree, a physicist with Berkeley Lab’s Materials Sciences Division, led a study in which organic molecules were used to form strong covalent bonds between carbon nanotubes and metal surfaces. This improved by six-fold the flow of heat from the metal to the carbon nanotubes, paving the way for faster, more efficient cooling of computer chips. The technique is done through gas vapor or liquid chemistry at low temperatures, making it suitable for the manufacturing of computer chips. (more…)

Engineering Bacterial Live Wires

By Guest PostMarch 13, 2013Sciencebacterial species, berkeley lab, bioelectronic systems, biological wire, caroline ajo franklin, cell membranes, cheryl goldbeck, common language, e coli, electron, electronic communication systems, energy, energy conversion techniques, guillaume cambray, heather jensen, information transfer, largus angenent, living cell, matt hepler, metabolic pathways, michaela teravest, molecular foundry, mr 1, mtrcab pathway, nanocrystalline iron oxide, nicole beedle, protein complex, shewanella oneidensis, strain, synthesis, university of california, vivek mutalik, yancey appling

Berkeley Lab scientists discover the balance that allows electricity to flow between cells and electronics

Just like electronics, living cells use electrons for energy and information transfer. Despite electrons being a common “language” of the living and electronic worlds, living cells cannot speak to our largely technological realm. Cell membranes are largely to blame for this inability to plug cells into our computers: they form a greasy barrier that tightly controls charge balance in a cell. Thus, giving a cell the ability to communicate directly with an electrode would lead to enormous opportunities in the development of new energy conversion techniques, fuel production, biological reporters, or new forms of bioelectronic systems. (more…)

Folding Funnels Key to Biomimicry

By Guest PostNovember 9, 2012Scienceafm, archaea, array, atomic force microscopy, babak sanii, bacteria, berkeley lab, biomimicry, biomolecular nanomachines, bones, carolyn bertozzi, cell, collagen matrices, collagen monomers, concept, fabrication, folding funnel, free energy, function, humans, jim deyoreo, key, kinetic traps, luis comolli, mica surface, molecular foundry, molecule level, molecules, multiple proteins, nanoscale synthesis, Nature, ordered structure, organic scaffolds, properties, protein folding, protein structure, proteins, pseudohexagonal symmetry, s layer, self assemble, seong ho shin, sungwook chung, surface layer, teeth

Berkeley Lab Finding that Protein Folding Funnels Also Apply to Self-Assembly Should Benefit Biomimicry and Nanosynthesis

Proteins are able to self-assemble into a wide range of highly ordered structures that feature a diverse array of properties. Through biomimicry – technological innovation inspired by nature – humans hope to emulate proteins and produce our own version of self-assembling molecules. A key to accomplishing this is understanding how protein-folding – a process critical to the form and function of a protein – is extended from individual proteins to complex assemblies.

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have now shown that a concept widely accepted as describing the folding of a single individual protein is also applicable to the self-assembly of multiple proteins. Their findings provide important guidelines for future biomimicry efforts, particularly for device fabrication and nanoscale synthesis. (more…)

Forcing the Molecular Bond Issue

By Guest PostSeptember 6, 2012Scienceadsorb, aerosol droplets, aleksandr noy, antibody, berkeley lab, binding free energy, biosensing assay, data, dfs, dynamic force spectroscopy, energy barrier, force spectra, formation, interaction, intermolecular bond, jim deyoreo, material, molecular bond, molecular foundry, molecular system, molecule, nanoscience center, nonlinear force, property, raymond friddle, rupture, single bond model, standard model, synthetic analogue, synthetic polymer, torsional force

New and Improved Model of Molecular Bonding from Researchers at Berkeley Lab’s Molecular Foundry

Material properties and interactions are largely determined by the binding and unbinding of their constituent molecules, but the standard model used to interpret data on the formation and rupturing of molecular bonds suffers from inconsistencies. A collaboration of researchers led by a scientist at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a first-of-its-kind model for providing a comprehensive description of the way in which molecular bonds form and rupture. This model enables researchers to predict the “binding free energy” of a given molecular system, which is key to predicting how that molecule will interact with other molecules.

“Molecular binding and unbinding events are much simpler than we have been led to believe from the standard model over the past decade,” says Jim DeYoreo, a scientist with the Molecular Foundry, a DOE nanoscience center at Berkeley Lab who was one of the leaders of this research. “With our new model, we now have a clear means for measuring one of the most important parameters governing how materials and molecules bind together.” (more…)

Form, Function and Folding: In Collaboration with Berkeley Lab, a Team of Scientists Move Toward Rational Design of Artificial Proteins

By Guest PostAugust 26, 2012Scienceamino acid, barney yoo, berkeley lab, bioinspired nanomaterial, blind structure, function, glenn butterfoss, ilya chorny, jonathan jaworski, ken dill, kent kirshenbaum, modeling, molecular foundry, n alkyl, natural selection, new york university, peptoid molecule, peptoid trimers, prediction, protein, protein sequence, qm, qm calculation, remd, richard bonneau, ronald zuckermann, stony brook university, structure, synthetic cousin, temple university, vincent voelz, xray crystallography

In the world of proteins, form defines function. Based on interactions between their constituent amino acids, proteins form specific conformations, folding and twisting into distinct, chemically directed shapes. The resulting structure dictates the proteins’ actions; thus accurate modeling of structure is vital to understanding functionality.

Peptoids, the synthetic cousins of proteins, follow similar design rules. Less vulnerable to chemical or metabolic breakdown than proteins, peptoids are promising for diagnostics, pharmaceuticals, and as a platform to build bioinspired nanomaterials, as scientists can build and manipulate peptoids with great precision. But to design peptoids for a specific function, scientists need to first untangle the complex relationship between a peptoid’s composition and its function-defining folded structure. (more…)

Better Organic Electronics

By Guest PostMarch 22, 2012Science5tba, allard katan, berkeley lab, conductance, crystal structure, d5tba, derivative, dh5tba, doe, electron, electron diffraction patterns, florent martin, intuition, lynn yarris, metal, miquel salmeron, molecular foundry, molecule, nanometer, nanoscience center, organic electronic device, organic film, organic semiconductor, pentathiophene butyric acid, plastic, polymer electronics, semiconductor, shaul aloni, silicon nitride membrane, tem, trial and error, virginia altoe

*Berkeley Lab Researchers Show the Way Forward for Improving Organic and Molecular Electronic Devices*

Future prospects for superior new organic electronic devices are brighter now thanks to a new study by researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab). Working at the Lab’s Molecular Foundry, a DOE nanoscience center, the team has provided the first experimental determination of the pathways by which electrical charge is transported from molecule-to-molecule in an organic thin film. Their results also show how such organic films can be chemically modified to improve conductance.

“We have shown that when the molecules in organic thin films are aligned in particular directions, there is much better conductance,” says Miquel Salmeron, a leading authority on nanoscale surface imaging who directs Berkeley Lab’s Materials Sciences Division and who led this study. “Chemists already know how to fabricate organic thin films in a way that can achieve such an alignment, which means they should be able to use the information provided by our methodology to determine the molecular alignment and its role on charge transport across and along the molecules. This will help improve the performances of future organic electronic devices.” (more…)

From Cancer Research to Energy Storage, Berkeley Lab Scientist Takes on Big Challenges

By Guest PostFebruary 3, 2012Scienceclean energy, CO2, energy, Environment, fossil fuel, hydrogen storage system, India, intel corporation, liquefied hydrogen, magnesium metal, metal hydride, molecular foundry, nanoparticle, optical spectroscopy, phase transition, plasmonic structures, rising star, rizia bardhan, Science, volumetric density

*Rizia Bardhan, a postdoc at the Molecular Foundry, selected to Forbes’ ’30 under 30′ list*

On a typical day, Rizia Bardhan walks through the doors of Lawrence Berkeley National Laboratory’s Molecular Foundry and immerses herself in the tricky business of tweaking optical spectroscopy equipment to study phase transitions in metal hydrides.

It’s fair to say that what she does is difficult to grasp. Why she does it is easy: “I want to help solve big problems. That’s why I’m here,” she says. (more…)