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Researchers Find New Way to Create ‘Gradients’ for Understanding Molecular Interactions

By Guest PostAugust 16, 2013Sciencealbena ivanisevic, amino acid, biological systems, biomolecular gradients, cell receptors, gradients, human body, indium gallium nitride, indium rich end, ingan, l arginine, lauren bain, ligands, molecular behavior, molecules, new technique, north Carolina, oxide accumulation, peptides, ph level, proteins, salah bedair, semiconductor material, state university, substrate, tania paskova

Scientists use tools called gradients to understand how molecules interact in biological systems. Researchers from North Carolina State University have developed a new technique for creating biomolecular gradients that is both simpler than existing techniques and that creates additional surface characteristics that allow scientists to monitor other aspects of molecular behavior.

A gradient is a material that has a specific molecule on its surface, with the concentration of the molecule sloping from a high concentration on one end to a low concentration at the other end. The gradient is used not only to determine whether other molecules interact with the molecules on the gradient, but to determine the threshold level at which any interactions take place. (more…)

Why Some Pain Drugs Become Less Effective Over Time

By Guest PostApril 22, 2012Healthdpdpe, graciela pineyro, journey, ligands, molecular mechanism, neural cell, opioid analgesics, opioid pain drugs, painkilling function, poppy plant, receptor recycling, sainte justine hospital, snc 80 t, university of montreal

Researchers at the University of Montreal’s Sainte-Justine Hospital have identified how neural cells are able to build up resistance to opioid pain drugs within hours. “A better understanding of these mechanisms will enable us to design drugs that avoid body resistance to these drugs and produce longer therapeutic responses, including longer-acting opioid analgesics”, lead author Dr. Graciela Pineyro said.

Humans have known about the usefulness of opioids, which are often harvested from poppy plants, for centuries, but we have very little insight into how they lose their effectiveness in the hours, days and weeks following the first dose. “Our study revealed cellular and molecular mechanisms within our bodies that enable us to develop resistance to this medication, or what scientists call drug tolerance,” she added. (more…)

Nanocrystals Go Bare: Berkeley Lab Researchers Strip Material’s Tiny Tethers

By Guest PostDecember 12, 2011Scienceanna llordes, april sawvel, berkeley lab, brett helms, carbon hydrogen bonds, chemical solution, delia milliron, devices, diodes, electronic conductivity, energy storage, environments, evelyn rosen, hydrocarbon, ink jet printer, lawrence berkeley national laboratory, ligand free nanocrystal, ligands, meerwein salt, metal oxides, metallic, molecular foundry, molecular vibrations, naked nanocrystals, nano ir, nanocrystal, nanoscale infrared spectroscopy, orders of magnitude, organic compound, organic ligands, organometallic molecules, oxidizing agents, photovoltaics, raffaella buonsanti, selenide nanocrystal, semiconductors, smart windows, solar fuels, spin, spray coating, stripping nanocrystals, strong acids, supercapacitor materials, surface ligands, tether like molecules, triethyloxonium tetrafluoroborate, universal technique, unstripped nanocrystal films, variety of applications

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have discovered a universal technique for stripping nanocrystals of tether-like molecules that until now have posed as obstacles for their integration into devices. These findings could provide scientists with a clean slate for developing new nanocrystal-based technologies for energy storage, photovoltaics, smart windows, solar fuels and light-emitting diodes.

Nanocrystals are typically prepared in a chemical solution using stringy molecules called ligands chemically tethered to their surface. These hydrocarbon-based or organometallic molecules help stabilize the nanocrystal, but also form an undesirable insulating shell around the structure. Efficient and clean removal of these surface ligands is challenging and has eluded researchers for decades. (more…)

Study Finds More Efficient Means Of Creating, Arranging Carbon Nanofibers

By Guest PostMarch 19, 2011Sciencecarbon nanofibers, diameter of nanofibers, ligand monolayers, ligands, nanofibers, nanoparticles, nickel nanoparticles, north carolina state university, organic molecules, time-consuming, trioctylphosphine

Carbon nanofibers hold promise for technologies ranging from medical imaging devices to precise scientific measurement tools, but the time and expense associated with uniformly creating nanofibers of the correct size has been an obstacle – until now. A new study from North Carolina State University demonstrates an improved method for creating carbon nanofibers of specific sizes, as well as explaining the science behind the method.

“Carbon nanofibers have a host of potential applications, but their utility is affected by their diameter – and controlling the diameter of nanofibers has historically been costly and time-consuming,” says Dr. Anatoli Melechko, an associate professor of materials science and engineering at NC State and co-author of a paper describing the study. (more…)

Tag Archives: ligands

Researchers Find New Way to Create ‘Gradients’ for Understanding Molecular Interactions

Why Some Pain Drugs Become Less Effective Over Time

Nanocrystals Go Bare: Berkeley Lab Researchers Strip Material’s Tiny Tethers

Study Finds More Efficient Means Of Creating, Arranging Carbon Nanofibers