jim deyoreo – Shamskm: A site to exchange knowledge and solutions

Folding Funnels Key to Biomimicry

By Guest PostNovember 9, 2012Scienceafm, archaea, array, atomic force microscopy, babak sanii, bacteria, berkeley lab, biomimicry, biomolecular nanomachines, bones, carolyn bertozzi, cell, collagen matrices, collagen monomers, concept, fabrication, folding funnel, free energy, function, humans, jim deyoreo, key, kinetic traps, luis comolli, mica surface, molecular foundry, molecule level, molecules, multiple proteins, nanoscale synthesis, Nature, ordered structure, organic scaffolds, properties, protein folding, protein structure, proteins, pseudohexagonal symmetry, s layer, self assemble, seong ho shin, sungwook chung, surface layer, teeth

Berkeley Lab Finding that Protein Folding Funnels Also Apply to Self-Assembly Should Benefit Biomimicry and Nanosynthesis

Proteins are able to self-assemble into a wide range of highly ordered structures that feature a diverse array of properties. Through biomimicry – technological innovation inspired by nature – humans hope to emulate proteins and produce our own version of self-assembling molecules. A key to accomplishing this is understanding how protein-folding – a process critical to the form and function of a protein – is extended from individual proteins to complex assemblies.

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have now shown that a concept widely accepted as describing the folding of a single individual protein is also applicable to the self-assembly of multiple proteins. Their findings provide important guidelines for future biomimicry efforts, particularly for device fabrication and nanoscale synthesis. (more…)

Forcing the Molecular Bond Issue

By Guest PostSeptember 6, 2012Scienceadsorb, aerosol droplets, aleksandr noy, antibody, berkeley lab, binding free energy, biosensing assay, data, dfs, dynamic force spectroscopy, energy barrier, force spectra, formation, interaction, intermolecular bond, jim deyoreo, material, molecular bond, molecular foundry, molecular system, molecule, nanoscience center, nonlinear force, property, raymond friddle, rupture, single bond model, standard model, synthetic analogue, synthetic polymer, torsional force

New and Improved Model of Molecular Bonding from Researchers at Berkeley Lab’s Molecular Foundry

Material properties and interactions are largely determined by the binding and unbinding of their constituent molecules, but the standard model used to interpret data on the formation and rupturing of molecular bonds suffers from inconsistencies. A collaboration of researchers led by a scientist at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a first-of-its-kind model for providing a comprehensive description of the way in which molecular bonds form and rupture. This model enables researchers to predict the “binding free energy” of a given molecular system, which is key to predicting how that molecule will interact with other molecules.

“Molecular binding and unbinding events are much simpler than we have been led to believe from the standard model over the past decade,” says Jim DeYoreo, a scientist with the Molecular Foundry, a DOE nanoscience center at Berkeley Lab who was one of the leaders of this research. “With our new model, we now have a clear means for measuring one of the most important parameters governing how materials and molecules bind together.” (more…)

Berkeley Lab Researchers Ink Nanostructures with Tiny ‘Soldering Iron’

By Guest PostNovember 8, 2011Scienceafm, atomic force microscope, berkeley lab, chemical patterns, chemical sensors, debin wang, dip pen nanolithography, electrical circuits, Environment, fabrication technique, gold surfaces, human hair, ink molecules, jim deyoreo, jonathan felts, mercaptohexadecanoic acid, molecular diffusion, nanofabrication techniques, nanoheater, nanometers, nanoscale structures, nanoscience, organic molecule, pharmaceuticals, role of temperature, sungwook chung, thermal dip pen nanolithography, university of illinois at urbana champaign, william p king

Researchers with the U.S. Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) have shed light on the role of temperature in controlling a fabrication technique for drawing chemical patterns as small as 20 nanometers. This technique could provide an inexpensive, fast route to growing and patterning a wide variety of materials on surfaces to build electrical circuits and chemical sensors, or study how pharmaceuticals bind to proteins and viruses.

One way of directly writing nanoscale structures onto a substrate is to use an atomic force microscope (AFM) tip as a pen to deposit ink molecules through molecular diffusion onto the surface. Unlike conventional nanofabrication techniques that are expensive, require specialized environments and usually work with only a few materials, this technique, called dip-pen nanolithography, can be used in almost any environment to write many different chemical compounds. A cousin of this technique — called thermal dip-pen nanolithography — extends this technique to solid materials by turning an AFM tip into a tiny soldering iron. (more…)

Tag Archives: jim deyoreo

Folding Funnels Key to Biomimicry

Forcing the Molecular Bond Issue

Berkeley Lab Researchers Ink Nanostructures with Tiny ‘Soldering Iron’