The enzyme-linked immunosorbent assay is one of the most sensitive biochemical or immunological tests. It is used a lot in medicine to detect presence or absence of antibodies raised to fight antigens or the specific antigen. The sensitivity of the test results from reliance on enzymes. As you are well aware, enzymes are highly specific. (more…)
Tag Archives: antibody
Findings are a promising step toward developing improved treatments for the disease
UCLA researchers have identified mechanisms that determine how advanced melanoma can become resistant to immune checkpoint inhibitors, a discovery that could lead to the development of new and improved treatments for the deadliest type of skin cancer. (more…)
A new study in the New England Journal of Medicine documents the high-profile failure of a promising drug, bapineuzumab, to slow cognitive decline in dementia patients. Dr. Stephen Salloway, the study’s lead author, says researchers have learned key lessons that they are eager to apply in new attempts to find effective treatments for Alzheimer’s disease.
PROVIDENCE, R.I. [Brown University] — Dr. Stephen Salloway pulls no punches in describing the results of two clinical trials of the Alzheimer’s drug bapineuzumab that he helped to lead. The antibody failed to produce cognitive improvement for volunteers compared to a placebo, he and colleagues report Jan. 23 in the New England Journal of Medicine. (more…)
ANN ARBOR — A glass plate with a nanoscale roughness could be a simple way for scientists to capture and study the circulating tumor cells that carry cancer around the body through the bloodstream.
Engineering and medical researchers at the University of Michigan have devised such a set-up, which they say takes advantage of cancer cells’ stronger drive to settle and bind compared with normal blood cells. (more…)
New and Improved Model of Molecular Bonding from Researchers at Berkeley Lab’s Molecular Foundry
Material properties and interactions are largely determined by the binding and unbinding of their constituent molecules, but the standard model used to interpret data on the formation and rupturing of molecular bonds suffers from inconsistencies. A collaboration of researchers led by a scientist at the U.S Department of Energy (DOE)’s Lawrence Berkeley National Laboratory (Berkeley Lab) has developed a first-of-its-kind model for providing a comprehensive description of the way in which molecular bonds form and rupture. This model enables researchers to predict the “binding free energy” of a given molecular system, which is key to predicting how that molecule will interact with other molecules.
“Molecular binding and unbinding events are much simpler than we have been led to believe from the standard model over the past decade,” says Jim DeYoreo, a scientist with the Molecular Foundry, a DOE nanoscience center at Berkeley Lab who was one of the leaders of this research. “With our new model, we now have a clear means for measuring one of the most important parameters governing how materials and molecules bind together.” (more…)
COLUMBUS, Ohio – New research adds to the growing body of evidence suggesting that there’s a link between allergies and reduced risk of a serious type of cancer that starts in the brain. This study suggests the reduced risk is stronger among women than men, although men with certain allergy profiles also have a lower tumor risk.
The study also strengthens scientists’ belief that something about having allergies or a related factor lowers the risk for this cancer. Because these tumors, called glioma, have the potential to suppress the immune system to allow them to grow, researchers have never been sure whether allergies reduce cancer risk or if, before diagnosis, these tumors interfere with the hypersensitive immune response to allergens. (more…)
University biologists have found a new molecule in fruit flies that is key to the information exchange needed to build wings properly. They have also uncovered evidence that an analogous protein may exist in people and may be associated with problems such as cleft lip, or premature ovarian failure.
PROVIDENCE, R.I. [Brown University] — As they work together to form body parts, cells in developing organisms communicate like workers at a construction site. The discovery of a new signaling molecule in flies by Brown University biologists not only helps explain how cells send many long-haul messages, but also provides new clues for researchers who study how human development goes awry, for instance in cases of cleft lip and palate. (more…)