Tag Archives: advanced melanoma

UCLA study sheds light on how advanced melanoma resists treatment

Findings are a promising step toward developing improved treatments for the disease

UCLA researchers have identified mechanisms that determine how advanced melanoma can become resistant to immune checkpoint inhibitors, a discovery that could lead to the development of new and improved treatments for the deadliest type of skin cancer. (more…)

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Roadblocking Cancer: How Combo Therapies Can Overcome Drug Resistance in Melanoma

About 50 to 60 percent of patients with melanoma have a mutation in the BRAF gene that drives the growth of their cancer. In clinical trials, most of these patients have responded remarkably well to two novel agents that inhibit the gene, but unfortunately, the response is almost always limited in duration, as the cancer develops a resistance to the drugs.

In a study published Aug. 1 as a Priority Report in the peer-reviewed journal Cancer Research, scientists at UCLA’s Jonsson Comprehensive Cancer Center tested a combination of small molecules that, when used with the BRAF inhibitors, may help overcome the drug resistance and extend the lives of those with advanced melanoma. (more…)

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