Tag Archives: jonsson comprehensive cancer center

You Are What You Eat: Low-Fat Diet with Fish Oil Slows Growth of Prostate Cancer Cells

Men who ate a low-fat diet with fish oil supplements for four to six weeks before having their prostate removed had slower cancer-cell growth in their prostate tissue than men who ate a traditional, high-fat Western diet, according to a study by researchers at UCLA’s Jonsson Comprehensive Cancer Center.

The researchers also found a change in the composition of cell membranes in both healthy cells and cancer cells in the prostates of men on the low-fat, fish oil–supplement diet. The membranes had heightened levels of omega-3 fatty acids from fish oil and decreased levels of omega-6 fatty acids from corn oil, which may directly affect the biology of the cells, though further studies are needed, said Dr. William Aronson, the study’s first author and a researcher with the Jonsson Cancer Center. (more…)

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Researchers Develop System that Finds Prostate Cancer Metastases Earlier

Researchers at UCLA’s Jonsson Comprehensive Cancer Center have developed a way to image the spread of a dangerous form of prostate cancer earlier than today’s conventional imaging techniques. The new method may allow oncologists to find and treat metastases more quickly and give patients a better chance at survival.

The gene-based imaging system targets castration-resistant prostate cancer, an aggressive form of the disease that has become resistant to the hormone treatment known as androgen-deprivation therapy. Once this treatment no longer works, the cancer will progress within 12 to 18 months, and the prognosis becomes grim, said senior study author Dr. Lily Wu, a professor of molecular and medical pharmacology and a Jonsson Cancer Center researcher. (more…)

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Roadblocking Cancer: How Combo Therapies Can Overcome Drug Resistance in Melanoma

About 50 to 60 percent of patients with melanoma have a mutation in the BRAF gene that drives the growth of their cancer. In clinical trials, most of these patients have responded remarkably well to two novel agents that inhibit the gene, but unfortunately, the response is almost always limited in duration, as the cancer develops a resistance to the drugs.

In a study published Aug. 1 as a Priority Report in the peer-reviewed journal Cancer Research, scientists at UCLA’s Jonsson Comprehensive Cancer Center tested a combination of small molecules that, when used with the BRAF inhibitors, may help overcome the drug resistance and extend the lives of those with advanced melanoma. (more…)

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